IV 37 22 8.1 1.7 – 39.0 0.009 2.7 0.4 – 20.0 0.329 EGFR FISH Amplification Normal 6 53 10 2.6 – 38.4 0.001 6.4 1.5 – 27.0 0.011 Abbreviations: CI ¼ confidence interval; EGFR ¼ epidermal growth factor receptor; FIGO ¼ International Federation of Gynecology and Obstetrics; FISH ...
Creatinine serum level augmentation of as little as 0.3 mg/dL could correspond to a great decrease in GFR, so that creatinine serum levels in the normal range or with minor changes could mask sever GFR alteration. Consequently, measuring and reporting both eGFR and creatinine serum level ...
17,18,19 It is well documented that inactivating mutations and downregulated expression or activity of TET proteins is closely associated with a wide range of cancers, including hematological malignancies and solid tumours.16,20 However, the function of TET proteins or their catalytic derivatives (e...
It is most likely that all of these factors affect a broad range of damage on DNA, on the precursors of DNA, on the replication and repair of DNA, and on the assembly and maintenance of chromosomes. Dosage ranges for X-rays range from daily doses of 50 to 200 roentgens for prolonged ...
Each study also included a broad range of representative alteration types for each class of alteration (substitution, insertion and deletion, copy number alterations, and rearrangements) in various genomic contexts across a broad selection of genes as well as analysis of genomic signatures including ...
Immunostaining pattern was also documented in normal salivary gland tissues as controls. Fluorescence in situ hybridisation As described in detail elsewhere (Sassen et al, 2008) TMA sections were mounted on charged slides (SuperFrost Plus; Menzel GmbH, Braunschweig, Germany). Haematoxylin – eosin-...
LncRNAs are novel subsets of noncoding RNAs, which regulate a variety of biological responses via a diverse range of mechanisms. Recent studies have shown that numerous changes in the expression of lncRNAs occur during the activation of the innate immune response and T-cell development, ...
lnc-EGFRΔR1, GAPDH or U6. c2: CD4+T cells were transduced with different doses of lnc-EGFR lentiviral particles and the association of lnc-EGFR with EGFR was determined by RIP assay using anti-EGFR antibodies and qPCR for lnc-EGFR. c3: The amplified sequence (Lnc-EGFR range from 337 ...
Relative IC50 values were calculated with the four-parameter nonlinear logistic equation and were classified into four response categories based on the tested concentration range: resistant (45.0656 mM) and minor (from 5.0656 mM to 0.4277 mM), moderate (from 0.4277 mM to 0.0361 mM) or strong ...
(Figure 2). Further analysis found that in the smoking subgroup, the OR value of SUVmaxand EGFR mutation was 0.947 (95%CI: 0.909–0.986;p= 0.008). In the normal CEA subgroup, the OR value of SUVmaxand EGFR mutation was 0.939 (95%CI: 0.906–0.973;p< 0.001). The characteristics of ...