The epidermal growth factor receptor ( EGFR ) has been implicated in a multiplicity of cancer-related signal transduction pathways such as cellular proliferation, adhesion, migration, neoangiogenesis and apoptosis inhibition, all of them are important features of cancerogenesis and tumour progression. ...
参考文献: [1]Subramanian J, Leighl NB, Choi YL, et al. Usage of epidermal growth factor mutation testing and impact on treatment patterns in non-small cell lung cancer: An international observational study[J]. Lung Cancer. 2022 Nov ...
EGFRmutation testing is usually optimized to detectEGFRmutations that have demonstrated significance, but there may be uncommon or uniqueEGFRmutations present in a tumor that are not detected. Although a mutation may be present in the tumor cells, if there is very little tumor tissue and/or when...
在美国和欧洲约有10%-15%的非小细胞肺癌患者伴有EGFR突变，在亚洲约有30%-40%的非小细胞肺癌患者伴有EGFR突变5-7，这些患者对表皮生长因子受体酪氨酸激酶抑制剂 (EGFR-TKI) 的治疗敏感，EGFR-TKI 可阻断驱动肿瘤细胞生长的细胞信号通路8。关于FLAURA2研究 FLAURA2是一项随机对照、开放标签、全球多中心的III期试验...
10. Szumera-Ciećkiewicz A, et al. EGFR Mutation Testing on Cytological and Histological Samples in Non-Small Cell Lung Cancer: a Polish, Single Institution Study and Systematic Review of European Incidence. Int J Clin Exp Pathol. 2013:6;2800-12. ...
Single Institution Study and Systematic Review of European Incidence. Int J Clin Exp Pathol. 2013:6;2. Cerner CancerMPact database.Accessed October 2023.Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for...
6. Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011;29:2121-27. ...
[8] Li W , Qiu T , Guo L , et al. Primary and acquired EGFR T790M-mutant NSCLC patients identified by routine mutation testing show different characteristics but may both respond to osimertinib treatment[J]. Cance...
在2017年的Precision LBx Summit(精准液体活检大会)上,来自于阿斯利康的肿瘤转化医学总监在其报告中明确提出”Beyond T790M: Detection of EGFR sensitizing mutation as a control”,利用EGFR原有敏感性突变,作为血浆ctDNA检测的阳性内参,一方面排除检测失败带来的假阴性结果,另一方面在之前的研究中已有证明,T790M与敏感...
5. Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27. ...