Also, the research study of the EGFR mutations should be performed for patients non eligible for chemotherapy (PS > 2). Molecular testing could be performed on biopsies, and also on cytology, knowing that there is a mismatch between the tumor and the metastasis for EGFR status. Samples should...
The EFS of (a) total ITT (n = 47), (b) Males and Females, (c) different mutation subtypes, (d) different TNM stage at diagnosis. P-value was calculated using stratified log-rank test, with p < 0.05 considered statistically significant. Source data are provided as a Source Da...
1A). Then we performed a small RNA-seq analysis to compare miR-21-5p and miR-21-3p expression between DTPCs and parental cells. We found that miR-21-5p and miR-21-3p expression levels increased 1.5 and 1.8-fold, respectively (Fig. 1B). Consistently, miR-21-3p was abundant compared ...
We tested 125 FFPET specimens of NSC LC with all 3 methods in a blinded manner; the cobas test was performed at both sites. Positive (PPA) and negative (NPA) percent agreements were determined for the cobas test vs. each of the other 2 methods. Specimens with disc...
Analysis for EGFR gene mutation was performed using a cytological specimen by means of the peptide nucleic acid–locked nucleic acid (PNA-LNA) polymerase-chain-reaction (PCR) clamp method as described previously [10, 11]. The specimen showed a deletion in exon 19 (L747-A750del T751S). We...
exon19mutationintheEGFRgene.Later,duringtherelapse, thesamemutationwasstillpresentand,inaddition,aT790M mutationinexon20ofEGFRwasfound.Thesubsequently acquiredresistanceagainstbotherlotinib,aswellasgefitinib wasmostlikelyaresultoftumorcellsacquiringtheT790M ...
Although EGFR-TKI treatment has shown excellent effects on EGFR mutation patients, acquired resistance has dampened long term benefit of these drugs. Targeting the other key signaling proteins or combinational treatment provide alternative strategies for LUAD patients. The multiple regulatory pathways are ...
EGFRm+晚期NSCLC一线治疗选择 目前治疗选择 药物在国内获批时间 2005 1stgeneration 2006 Chemotherapy Gefitinib Gefitinib+Pemetrexedcarbo Erlotinib Erlotinib+Bevacizumab 2011 2ndgeneration 2017-2018 3rdgeneration 2019 Icotinib AfatinibDacomitinib* Osimertinib）▷ •Dacomitinib未在中国批准上市◁奥希替尼一线适应症...
Of patients with PD while on afatinib, 55.3% were investigated for resistance mechanisms with exon 20 T790 M mutation detected in 42.0% of them. Conclusions Afatinib is an effective first-line treatment for patients with EGFR-mutant advanced NSCLC with a good response rate and long survival...
inferred from the single-cell transcriptome analysis, we performed the multiplexed immunofluorescence (IF) staining in archival tissue specimens of the same samples. We could obtain results of multiplexed IF for nine of the prior samples, because the sample quantity for the P3 patient was not suffic...