Thecobas® EGFR Mutation Test v2 is a real-time PCR test that identifies 42 mutations in exons 18, 19, 20 and 21 of the epidermal growth factor receptor (EGFR) gene, including the T790M resistance mutation. It is designed to enable testing of both tissue and plasma specimens with a sing...
Is EGFR gene mutation testing necessary in smokers with non-small cell lung cancer?Objective Previous studies have proven that cumulative smoking dose predicts the prevalence of epidermal growth factor receptor (EGFR) mutations. The aim of this study was to investigate the relationship between smoking...
The disease remission rate and disease control rate of EGFR gene mutation patients were higher than those of EGFR gene wild type patients (P<0.05). The median progression free survival was 10.354 months in the EGFR gene mutation group and 9.212 months in the EGFR gene wild type group. The ...
美国当地时间2023年6月6日,吴一龙教授将携EVEREST研究,即“佐利替尼”(AZD3759)针对伴中枢神经系统(CNS)转移EGFR敏感突变的晚期非小细胞肺癌(NSCLC)患者的III期随机对照研究,登陆今年ASCO口头报告环节,向世界同行展现又一个中国之声,率先填补EGFR敏感突变NSCLC伴CNS转移治疗领域的I级循证空白。 佐利替尼的随机对照临...
[34] Kosaka T, Yatabe Y, Endoh H, et al. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 2006;12:5764-5769. [35] Onitsuka T, Uramoto H, Nose N, et al. Acquired resistance to...
产品名称 cobas EGFR Mutation Test v2 申请号 P120019 S018 申请类型 pma 产品分类 Ⅲ类 分类名称 Somatic Gene Mutation Detection System 产品分类码 OWD 申请企业 ROCHE 申请企业/街道1 4300 HACIENDA DRIVE 申请企/业街道2 PO BOX 9002 ...
Several methods with higher detection sensitivity can detect mutations present at very low levels (1–5% of EGFR gene copies mutated), allowing the possibility of mutation detection when tumor cell proportion is less than 10% of the test sample. How Should the Biopsy Material Be Prepared for ...
Gene 366: 2–16. Article CAS Google Scholar Normanno N, Pinto C, Taddei G, Gambacorta M, Castiglione F, Barberis M, Clemente C, Marchetti A (2013) Results of the First Italian External Quality Assurance Scheme for somatic EGFR mutation testing in non-small-cell lung cancer. J Thorac ...
Cytology smears as diagnostic material for EGFR gene testing in non-small cell lung cancer. Tumori. 2015 Nov 14;101(6):e151-3. Pubmed ID 26108238Lewandowska MA, Czubak K, Klonowska K, Jozwicki W, Kowalewski J, Kozlowski P. The Use of a Two-Tiered Testing Strategy for the Simultaneous ...
The recent shift from single gene testing to novel comprehensive detection platforms along with the development of new generation tyrosine kinase inhibitors, targeting both common and uncommon EGFR-mutations, is leading to a progressive increase in the number of patients who may benefit from targeted ...