Economic losses in the pig industry are a direct result of the global problem of diarrhea. There is increasing interest in discovering novel antibiotic replacements to resolve this matter. This study, accordingly, aimed to assess the prebiotic activity of low-molecular-weight hydrolyzed guar gum (...
2a). ASK120067 significantly inhibited p-EGFR L858R/T790M at a concentration as low as 0.1 nM and almost completely inhibited p-EGFR L858R/T790M at 1 to 10 nM (Fig. 2a). Similar results were obtained in PC-9 cells, as evidenced by the decreased levels of EGFR exon19del phosphorylation ...
T cells reactive with the EGFR875–889 epitope could be detected in the blood of HNSCC patients. EGFR875–889-reactive CD4 T cells were also able to recognise several peptide analogues derived from homologous regions of EGFR family members, HER-2, HER-3 and c-MET. Finally, we examined the...
Pre-hospital use of a non-invasive pelvic binder device (NIPBD) is a critical measure in minimizing blood loss and improving survival prospects for patients with unstable pelvic ring injuries. Initial prehospital assessments, however, sometimes fail to recognize the presence of unstable pelvic ring ...
CTCs are rare events in the blood of patients and are believed to represent the epithelial population from a primary tumour of epithelial origin, thus EpCAM immunoisolation is considered an appropriate strategy. The controversy stems from the impact that the more aggressive mesenchymal tumour ...
in NCI-H1975 cells, with similar or even more effective potency than osimertinib (Fig.2a). ASK120067 significantly inhibited p-EGFRL858R/T790Mat a concentration as low as 0.1 nM and almost completely inhibited p-EGFRL858R/T790Mat 1 to 10 nM (Fig.2a). Similar results were obtained in PC-...
Epidermal growth factor receptor (EGFR), the receptor for members of the epidermal growth factor family, regulates cell proliferation and signal transduction; moreover, EGFR is related to the inhibition of tumor cell proliferation, angiogenesis, invasion
Non-small-cell lung cancer (NSCLC) is an aggressive disease in which vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) are implicated in tumour growth, tumour resistance to radiation and chemotherapy, and disease relapse. We have investigated the anti-tumoural effects of...
The overrepresentation of blood group O in cases with PML was in line with a previous publication. Larger studies are warranted to assess a potential value of host genetic markers, such as the ABO status, for PML risk prediction during immunotherapy. Keywords: ABO blood group, natalizumab, PML...
EGFR tyrosine kinase inhibitors (TKIs) have transformed the treatment of EGFR-mutated non-small cell lung carcinoma (NSCLC); however, therapeutic resistance remains a clinical challenge. Acquired secondary EGFR mutations that increase ATP affinity and/or