EGFR expression levels in CRC cell lines.Kohei, ShigetaTetsu, HayashidaYoshinori, HoshinoKoji, OkabayashiTakashi, EndoYoshiyuki, IshiiHirotoshi, HasegawaYuko, Kitagawa
Expression of astrocyte‐elevated gene‐1 indicates prognostic value of fluoropyrimidine‐based adjuvant chemotherapy in resectable stage III colorectal ca... A significant positive correlation was observed between AEG‐1, TS, ERCC1, EGFR, and VEGF gene expression levels in CRC cell lines, and low ...
Purpose To exp1ore the expression and c1inica1 significance of epiderma1 growth factor receptor( EGFR)and human epi-derma1 receptor-2(HER-2)in co1orecta1 c... 杨悦,万义增,陈素贤,... - 《临床与实验病理学杂志》 被引量: 0发表:...
expression of epidermalgrowth factor receptor (EGFR)and vascularendothelialgrowthfactor(VEGF)incolorectalcarcinoma(CRC) and adj acentnormalcolorectalmucosa by immunohistochemical staining.To investigate themRNA expression ofEGFRincolorectalcarcinomaand adjacent ...
我们通过对西妥昔单抗原发或继发耐药的人类CRC细胞系来评估EPHA2作为抗EGFR 单抗的耐药机制[16, 68]。研究发现西妥昔单抗联合EPHA2的小分子酪氨酸抑制剂—ALW-II-41-27可以恢复抗EGFR治疗的敏感性,从而显著提升抗肿瘤活性[16]。综合这些数...
A simple and reproducible scoring system for EGFR in colorectal cancer: application to prognosis and prediction of response to preoperative brachytherapy The aim of this study was to determine the predictive and prognostic value of epidermal growth factor receptor (EGFR) expression in rectal cancers ...
The factors driving PPIN rewiring are multifactorial including changes in protein expression and phosphorylation. Mathematical modelling also suggests that the binding dynamics of low and high affinity KRAS interactors contribute to rewiring. PPIN rewiring substantially alters the composition of protein ...
目前发现的EGFR配体有多种，EGFR在正常结直肠黏膜组织中呈弱表达或不表达，而在结直肠腺瘤和CRC组织中呈阳性表达，且阳性表达率后者高于前者[4]。在CRC细胞中，EGFR异常分布到细胞膜的顶端，这与正常人肠上皮细胞中EGFR的表达明显不同。李月敏等[5]研究表明，患者肿瘤组织EGFR的阳性表达率为69％，EGFR在CRC组织中...
In this study, we used this assay to evaluate the association between EGFR expression and trastuzumab response in the North Central Cancer Treatment Group (NCCTG) N9831 trial. We then validated the result in a retrospectively collected trastuzumab-treated metastatic breast cancer cohort from Greece....
Employing four cellular receptors, we embarked to identify aggressive tumour behaviour and impact of surrogate marker expression on patient prognosis. Methods One-hundred eighty-three CRC patients were enrolled in our investigation that focused on an array of biological markers, namely epidermal growth ...