Results TS_TL model demonstrated promising performance in predicting the EGFR mutation status, with an AUC of 0.883 (95%CI = 0.849–0.917) in the training set and 0.730 (95%CI = 0.629–0.830) in the independent test set. Particularly in advanced LADC, the model achieved an AUC of...
We hypothesize that the discrepancy between the five studies can be explained by the small sample numbers and by different staining and evaluation methods utilized. C-kit and VEGF-R2, together with VEGF-R1, VEGF-R3 and PDGFRs, are targets of two multi- targeted inhibitors Sorafenib (Nexavars)...
Genomic alterations were identified at osimertinib progression (liquid biopsy in blood or pleural fluid) considering mutations (A) and amplifications (B). All patients in cohort A had two or more commutations, while in cohort B, only three had a commutation.CAmplifications identified at the time...
The most common TEAE resulting in RAM or PBO dose delays was blood bilirubin increased (8 [14.0%] on RAM + ERL vs 4 [7.3%] on PBO + ERL). Dose omissions due to blood bilirubin increased (2 [3.5%] on RAM + ERL vs 4 [7.3%] on PBO + ERL) and proteinuria (3 [5.3%]) on ...