My blood test from last week has come back as abnormal. I can see my eGFR level has gone from 56 to 43 and creatine from 106 to 132 umol/l within 6 months. I’m a bit worried as to why it has dropped like this. I’m early 40s. Since Jan I have really reduced alcohol to alm...
(ARMS). RESULTS: Compared with matched tumor tissue, the concordance rate of EGFR mutation status in plasma and serum was 73.6% and 66.3%, respectively. ARMS for EGFR mutation detection in blood showed low sensitivity (plasma, 48.2%; serum, 39.6%) but high specificity (plasma, 95.4%; serum...
Subgroup analyses were conducted, focusing exclusively on data from distinct patient demographics. Small-study effects were examined using funnel plots and statistically assessed with the Begg’s test. A two-sidedP < 0.05 was considered statistically significant [50]. Results Characteristics of the...
EGFR tyrosine kinase inhibitors (TKIs) have transformed the treatment of EGFR-mutated non-small cell lung carcinoma (NSCLC); however, therapeutic resistance remains a clinical challenge. Acquired secondary EGFR mutations that increase ATP affinity and/or
To test, we classified and grouped cell lines per co-resistance case according to their level of basal EGFR expression (low and high EGFR-expressing cell lines). Indeed, among all the RTKs evaluated, AXL notably emerged as the highest-ranking RTK that displayed strong correlation with EGFR ...
The associations between categorical vari- ables were determined using the w2 or Fisher's exact test. The statistical differences of the average values were tested using a Student's t-test and analysis of variance, followed by Bonferroni's test. The impact of the different variables on long-...
Tail blood glucose was measured at 0, 15, 30, 60 and 120 min after injection. Statistical analysis Data are presented as the mean ± SEM of at least three independent experiments. Statistical comparisons were made using a two-tailed Student’s t test for unpaired data when comparing two ...
The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds J. Am. Chem. Soc., 142 (2020), pp. 19622-19630, 10.1021/jacs.0c08691 View in ScopusGoogle Scholar 47 M. McKeague, V. Calzada, L. Cerchia, M. DeRosa, ...
EGFR was also detected in the nuclear fraction at low levels. These fractions were subjected to immunoprecipitation with the anti-HDAC1 antibody to examine the HDAC1-EGFR interaction (Fig. 5d), and relative amounts of the interactions either in the membrane-bound organelle fraction (Fig. 5e) or...
Combinations of Low-Frequency Genetic Variants Might Predispose to Familial Pancreatic Cancer. J Pers Med. 2021;11(7). Molina-Vila MA, Bertran-Alamillo J, Gasco A, Mayo-de-las-Casas C, Sanchez-Ronco M, Pujantell-Pastor L, et al. Nondisruptive p53 mutations are associated with shorter ...