免费在线预览全文 EGFR检测血浆优于血清-周彩存 Trans la t iona l Onco logy Volume 7 Number 3 June 2014 pp. 341–348 341Peripheral Blood for Epidermal Growth Factor Receptor Mutation Detection in Non-Small Cell Lung Cancer PatientsXuefei Li*,1, Ruixin Ren?,1, Shengxiang Ren?, Xiaoxia Chen?
Significance of differences was determined by Student’s t test (∗p < 0.05, ∗∗p < 0.01). d Proposed mechanism for the efficacy of the combination strategy in ASK120067-resistant NCI-H1975 cells Full size image On the basis of our findings, the potential mechanism whereby Ack1/AKT ...
Subgroup analyses were conducted, focusing exclusively on data from distinct patient demographics. Small-study effects were examined using funnel plots and statistically assessed with the Begg’s test. A two-sidedP < 0.05 was considered statistically significant [50]. Results Characteristics of the...
All patients had EGFR 20ins documented by local testing at enrollment, 143 of whom (95.3%) were further confirmed by central testing on tumor tissue samples (n = 143) and/or paired peripheral blood samples (n = 117). A total of 38 distinct EGFR 20ins variants were identified (...
Tail blood glucose was measured at 0, 15, 30, 60 and 120 min after injection. Statistical analysis Data are presented as the mean ± SEM of at least three independent experiments. Statistical comparisons were made using a two-tailed Student’s t test for unpaired data when comparing two ...
HER2-XPAT and HER2-uTCE induced robust and comparable activation of intratumoral CD4+ and CD8+ T cells, whereas no trends for T-cell activation were apparent in blood samples in which HER2 was not present. Statistical differences in TGI and T-cell activation for test compounds versus vehicle ...
It was also found that AQP2 protein expression is reduced in kidney cancer tissue, however, the number of clinical samples have to be expanded, with combination of liquid biopsy (blood, urine) analysis to explore the application potential of MIAC and AQP2 as biomarkers for kidney cancer ...
various parameters, including total cholesterol, triglyceride levels, high- and low-density lipoprotein cholesterol (HDL-C and LDL-C, respectively), fasting blood glucose, creatinine, uric acid, alanine aminotransferase (ALT), blood urea nitrogen, and aspartate aminotransferase (AST), were assessed. ...
EGFR tyrosine kinase inhibitors (TKIs) have transformed the treatment of EGFR-mutated non-small cell lung carcinoma (NSCLC); however, therapeutic resistance remains a clinical challenge. Acquired secondary EGFR mutations that increase ATP affinity and/or
“previously unknown, unclear tractability” were clearly separated from the remaining genes on the basis of low values of all objectives across the board, except the log fold-change values from the RNA-Seq study 3. This analysis suggests that in general the experts tend to prioritize genes ...