Subgroup analyses were conducted, focusing exclusively on data from distinct patient demographics. Small-study effects were examined using funnel plots and statistically assessed with the Begg’s test. A two-sidedP < 0.05 was considered statistically significant [50]. Results Characteristics of the...
*p < 0.05, **p < 0.01, ***p < 0.001; all by two-tailed Student’s t-test. Source data are provided as a Source data file. Full size image We next investigated whether the effects of Grp94 on cell proliferation and NSCLC tumor growth is dependent on FBXL2. As shown ...
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis
The first blood sample was collected at the time of diagnosis before the start of treatment. Circulating free DNA (cfDNA) was quantified using the QX200 Droplet Digital PCR System (Bio-Rad Laboratories, Hercules, CA). For the EGFR multiplex assays, a final PCR mix volume of 20 μL was ma...
The probability of developing dementia by age 80, given non-normal blood pressure between the ages of 45 and 54, was 153% (95% confidence interval: 69% to 223%). Stage 2 hypertension (119%-213%) demonstrated the prevalence of the strongest PAFs, indicating a potential causal link. The ...
The clinical data of patients were collected, including gender, age, and routine blood test results 2 weeks before EGFR-TKIs treatment. Patients who received EGFR-TKIs first-line treatment were followed up, and the follow-up content included the follow-up treatment effect, whether recurrence or ...
et al. Development and clinical utility of a blood-based test service for the rapid identification of actionable mutations in non-small cell lung carcinoma. J. Mol. Diagn. 19, 404–416 (2017). Article CAS PubMed Google Scholar Frampton, G. M. et al. Development and validation of a ...
cardiovascular death, all-cause death, any adverse event, any serious adverse event using the STATA software. Sensitivity analysis and subgroup analysis was also conducted when data was with high heterogeneity. Publication bias was assessed by Egger's test. When p value < 0.05 were considered...
The gene alterations of the three PDXs were listed in Supplementary Table 4, note that the alterations in PDX-1R and PDX-2R were numerous due to the lack of gene mutation spectrum of paired normal tissue or blood to eliminate the redundant information of gene alterations. Even so, there ...
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis