We hypothesize that the discrepancy between the five studies can be explained by the small sample numbers and by different staining and evaluation methods utilized. C-kit and VEGF-R2, together with VEGF-R1, VEGF-R3 and PDGFRs, are targets of two multi- targeted inhibitors Sorafenib (Nexavars)...
(from either fresh, cryopreserved or fresh frozen peripheral blood or skin) at the Children’s Cancer Institute (Australia), as described previously15. WGS was conducted at the Kinghorn Centre for Clinical Genomics at the Garvan Institute of Medical Research (Australia), DNA methylation array ...
HER2- XPAT and HER2-uTCE induced robust and comparable activation of intratumoral CD4+ and CD8+ T cells, whereas no trends for T-cell activation were apparent in blood samples in which HER2 was not present. Statistical differences in TGI and T-cell activation for test compounds versus vehicle...
A Student's t-test was used to compare data between two groups and for multiple group comparisons, one-way ANOVA and the Bonferroni post hoc test were applied. The differences were considered statisticaly significant at P<0.05. Data are expressed as the means ± SEM. Results Engineered toxin-...
Ovarian cancer metastasizes generally through direct dissemi- nation from the primary site into peritoneal cavity, without intravasation and extravasation of blood vessels.4 In fact, most of patients with advanced ovarian cancer present with omental metastasis.5,6 In omentum, stromal fibroblasts are ...
+T cells, whereas no trends for T-cell activation were apparent in blood samples in which HER2 was not present. Statistical differences in TGI and T-cell activation for test compounds versus vehicle were assessed using mixed-effects multiple comparison analyses followed by Tukey’s post hoc test...