义翘神州开发了一系列具有高生物活性、高批间一致性和高纯度的重组细胞因子(如EGF、FGF2、NOG、BMP4、RSPO1等)及其受体和激活剂(如:EGFR、FGFR1、FGFR2、c-MET、HGFAC、BMPR2等)试剂产品,包括重组蛋白、抗体等试剂,以实现肠道类器官的最佳生长以及疾病模型研究。
图5.AG1478抑制EGFR对Dermo1+-HB-EGF小鼠软骨和骨缺损的修复作用。(A)WB结果显示,AG1478抑制了Dermo1-HB-EGF小鼠骨髓基质细胞中的EGFR活化。从小鼠骨髓中分离骨髓间充质干细胞,并用蛋白印迹法进行分析。小鼠从1个月大开始接受AG1478治疗2个月(A-K)。(B)AG1478挽救了Dermo1-HB-EGF小鼠膝关节的异常形态。(C)AG...
(A)WB结果显示,AG1478抑制了Dermo1-HB-EGF小鼠骨髓基质细胞中的EGFR活化。从小鼠骨髓中分离骨髓间充质干细胞,并用蛋白印迹法进行分析。小鼠从1个月大开始接受AG1478治疗2个月(A-K)。(B)AG1478挽救了Dermo1-HB-EGF小鼠膝关节的异常形态。(C)AG1478挽救了Dermo1-HB-EGF小鼠股骨长度的减少。n=4。(D)AG1478挽救...
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family...
(IEC6) was used as an in vitro model, and Confocal laser scanning microscope (CLSM), Flow cytometry (FCM), Indirect immunofluorescence assay (IFA), Western-blotting (WB), and Quantitative real-time RT-PCR (QRT-PCR) methods were used to explore the effects of inflammation on EGF/EGFR ...
EGF Receptor (EGFR1) Mouse mAb (IP Specific) (Sepharose® Bead Conjugate) is useful for immunoprecipitation assays. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated EGF Receptor (EGFR1) Mouse mAb (IP Specific) #2256....
Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif-containing GTPase-activating protein 1 (IQGAP1) provides a molecular platfor
Finally, as an EGFR ligand, HBEGF can bind to the EGFR receptor and thus regulate the expression of downstream signalling pathways. Consequently, the signalling pathways downstream of the miR-760/HBEGF signalling axis also remain to be identified....
结果显示与对照组相比,Il-4rαfl/flClec4f-Cre+/-小鼠肝脏中磷酸化(p)-表皮生长因子受体(p-EGFR)水平降低,表明肝巨噬细胞中的IL-4/IL-4Rα信号可以调节一种或多种EGFR配体。在IR损伤后第3天从Il-4rαfl/flClec4f-Cre+/-...
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family...