We utilized an in vivo preclinical model to perform a PK-PD analysis of systemic TDF PrEP for vaginal HIV acquisition. TDF PrEP prevented vaginal HIV acquisition in a dose-dependent manner. PK-PD modeling of tenofovir (TFV) in plasma, female reproductive tract tissue, cervicovaginal lavage ...
Beyond the Biomedical: Preexposure Prophylaxis Failures in a Cohort of Young Black Men Who Have Sex With Men in Atlanta, Georgia Human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) has high biomedical efficacy; however, awareness, access, uptake, and persistence on ther... DP Sero...
After decades of intensive HIV prevention research and more than a few disappointments, we are now in an "era of evidence" in which there are new tools to help end the epidemic including PrEP,1–3 voluntary medical male circumcision,4,5 and treatment as prevention for HIV-positive people. ...
In addition, those subjects infected with HIV (human immunodeficiency virus) and those who were otherwise immuno- compromised were not eligible for enrolment. Lifetime number of sexual partners was not an inclusion or exclusion criterion. The Institutional Review Board at each participating centre ...
19 Endotoxin-free pVAX and pVAX-tpaNS1 DNA plasmids were prepared using QIAGEN endotoxin-free Gigaprep kits. Prior to all animal studies, plasmid integrity was analyzed on 0.8% agarose gel electrophoresis in the presence or absence of HindIII enzyme digestion, which was performed according to ...
The criteria for exclusion were: individuals with a history of hepatitis C or hepatitis D; positive antibodies against HCV, HDV, or HIV; other inflammatory diseases such as rheumatoid arthritis, diabetes, or autoimmune hepatitis; hypertension; kidney disease; or recent infectious diseases. The ...
news Colchicine Drug-Drug Interactions May Not Affect Safety, Efficacy Procedures Antiretroviral Therapy for HIV Infection news Prevalence of Dementia in Homeless Twice That in Housed news No HIV Infections After Twice-a-Year PrEP Drugs salmeterol Drugs vonoprazan/amoxicillin/clarithromycin Log...
The widespread uptake of biomedical prevention such as pre-exposure prophylaxis (PrEP) for HIV is likely to lead to further increases in rectal chlamydia among MSM [11]. Data from PrEP implementation studies in the US and Australia are showing an increased incidence of rectal STIs among MSM ...
Conference|ASN Kidney Week - American Society of Nephrology Kidney Week Peter Stenvinkel, MD, PhD, FASN, full professor and senior lecturer at Karolinska University Hospital, Karolinska Institutet, discusses the therapeutic strategies or treatments for vascular calcification that have been fo...
Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART...