These biological rhythms are known as circadian rhythms and we know they are particularly strong in birds. D. As the long-term effects of disrupting circadian rhythms are yet to be discovered, we should take care to ensure the health of shift-workers and those with genetic conditions that ...
In particular, disrupting homeostatic oscillations in endocrine tissues and the hormones that these tissues regulate can have cascading effects on physiology and behavior. Accumulating evidence suggests that chronic disruption of circadian organization of endocrine function may lead to metabolic, reproductive,...
Disrupting the circadian clock: genespecific effects on aging, cancer, and other phenotypes EA Yu,DR Weaver 被引量: 0发表: 2010年 Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis The mammalian circadian system has been implicated in the...
Last but not least, ALAN profoundly affected taxonomic compositions, species diversity and community structure of intestinal microbiota of birds. We concluded that ALAN may cause bird health damage by disrupting circadian rhythm, inhibiting melatonin release and altering intestinal microbiota. Melatonin ...
Transcriptomic analysis revealed that PFOA also disrupts fatty acid metabolism and alters the expression of immune-responsive genes in Drosophila. In the U-2 OS human osteosarcoma cell line, we examined the impact of PFOA on circadian rhythm regulatory proteins and discovered that, compared with ...
Mn ++ does not appear to be producing phase shifts by disrupting the flux of Ca ++ across the plasma membrane since changing such fluxes by either raising extracellular Ca ++ (50 mM) or lowering extracellular Ca ++ with EGTA (Ca ++ <10 7 M) did not cause phase shifts in the rhythm. ...
(DON) promoted antitumor immunity by greatly favoring OXPHOS over glycolysis in CD8+T cells while disrupting the metabolism of cancer cells.171Notably, DON showed the ability to significantly inhibit the generation and recruitment of MDSCs and to reprogram M2-like TAMs into proinflammatory TAMs, ...
“circadian rhythm signaling”, all of which have been associated with ASD. Similarly, “glutamate receptor signaling” and “axonal guidance signaling” were also present among the top canonical pathways significantly associated with DEGs in the female hippocampus (P-value < 0.05; Supplementary ...
circadian rhythms would be expected to drift and become desynchronised. The result, as discussed below in the sub-section ’Disrupting the clock’, will be a weakened health status of the patient. Light does more than regulate the timing of circadian rhythms – it also has a direct effect ...
This finding reflects the toxic effects of imidacloprid on bees, which attempt to increase detoxification capacity to compensate for the defense defect caused by imidacloprid disrupting antioxidant capacity. Given that melatonin has been found in this study to contribute to redox homeostasis and enhance ...