DepressionAnxietyBipolar disorderSchizophreniaLight at nightNight shift workJet lagDuring the evolution of life, the temporal rhythm of our rotating planet was internalized in the form of circadian rhythms. Cir
In a recent study, researchers examined whether or not melatonin is also an effective insomnia treatment for individuals with delayed circadian rhythms.
Through comparing post-mortem brain samples from mentally healthy donors and those of people who had major depression at the time of their death, researchers found that people with clinical depression show disrupted circadian rhythms across brain regions. In healthy people, of the 16 genes that show...
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression 2018, Frontiers in Psychiatry Show abstract Recent advances in the utilization of tea active ingredients to regulate sleep through neuroendocrine pathway, immune system and intestinal microbiota 2023, Critical Reviews in Food Science ...
In mammals, constant light has been reported to induce circadian disruption, fatigue, irritability, depression and anxiety [9, 10]. In searching for the underlying mechanisms, many studies focus on melatonin, a hormone secreted by the pineal gland in response to the external light cues [11]. ...
Normal behavior and physiology depend on a near 24-hour circadian release of various hormones. Disruption in hormone release can lead to various pathologies, including affective disorders like anxiety and depression, and metabolic disorders like diabetes and obesity. ...
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In this regard, several studies also documented that a constant light environment disturbs circadian rhythms in both human and animal models (LeGates et al., 2014). For instance, female hamsters exposed to low light during the night cycle showed a depression-like phenotype and impaired learning ...
University students in China who reported disruptions in circadian rhythms such as diet and sleep were more likely to demonstrate higher anxiety and depressive symptoms during lockdown (Tao et al., 2021). Both regular primary and secondary routines were inversely associated with the risks of anxiety...
We now propose that SF induces sleepiness via initial and rather selective activation of TNF-α pathways, which then will activate an NADPH-dependent oxidative stress cascade that will ultimately lead to cognitive dysfunction along with anxiety-like behaviors and depression (Figure 7). Figure 7 ...