Franciszkiewicz K, Boissonnas A, Boutet M, Combadiere C, Mami- Chouaib F (2012) Role of chemokines and chemokine receptors in shaping the effector phase of the antitumor immune response. Cancer Res 72: 6325-6332
Effector proteins secreted by plant pathogenic fungi are important artilleries against host immunity, but there is no precedent of such effectors being explored as antifungal targets. Here we demonstrate that MoErs1, a species-specific effector protein s
Naïve CD4+T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, bulk RNA-seq, and single-cell RNA-seq of over 40,000 human naïve ...
Conclusion: In this prospective phase 2 trial, siltuximab demonstrated a high response rate (79%) and rapid time to resolution (median 1 hour) of CRS following CAR T-cell therapy. However, the efficacy for ICANS was modest (45%). Importantly, no new adverse events were attributable to ...
PD assays and other immune endpoints demonstrated immune suppression, not stimulation. Due to the inverted immune response at higher doses and the onset of ADAs, additional repeat-dose toxicity studies of BMS-986178 in monkeys (that would typically be required to support Phase 3clinical trialsand ...
To demonstrate that γδT-lymphocytes are also amplified in vivo, we have conducted a multicenter phase II clinical study comprising of 45 patients who presented with advanced FL in relapse or refractory relapse, since last line of therapy, with a median time of 19.1 months [Protocol No. IPH1...
This signal steadily increased and peaked during the terminal survival phase of illness (Figure 6E). In parallel with the bioluminescence increase from the sinus region, these infected mice became ataxic and displayed a disturbance in equilibrium. These data demonstrate that bioluminescence imaging can...
The limited necessity for peripheral adaptive immune activation for the pathogenesis of subpial (type 3) demyelination may in part explain the difficulties encountered in therapeutically targeting the ongoing tissue damage in the progressive phase of the disease. Importantly, CCR2+ monocytes play a ...
Plant pathogens secrete numerous effectors to promote host infection, but whether any of these toxic proteins undergoes phase separation to manipulate plant defence and how the host copes with this event remain elusive. Here we show that the effector FolSvp2, which is secreted from the fungal path...
(B8) were very similar, both of them had anMKI67hiTUBBhiHMGB2hiprofile and the maximal proportion of cells in the S + G2/M phase (Supplementary Fig.3a). P8 and B8 were designatedMKI67hieffector subsets. Although theFOXP3hiandMKI67hiTregcell subsets were highly conserved across PB...