Mesenteric lymph nodes (MLNs) and their pathogenic CD4+T cells were important to enteropathy occurrence and exacerbation when the mice were fed an egg-white (EW) diet. EW-fed OVA23-3 mice also developed bone loss and increased CD44hiCD62LloCD4+T cells in the MLNs and bone marrow (BM)...
Naive T cells are CD44-CD62L+. Central memory T cells are CD44+CD62L+. Effector memory and effector cells are CD44+CD62L-. To distinguish effector memory and effector cells, observe expression of CD127/IL-7Rα on the CD44+CD62L- population. Effector memory cel...
Effector memory T cells are associated with atherosclerosis in humans and animal models. J Am Heart Assoc 2012;1:2741.Ammirati E, Cianflone D, Vecchio V, Banfi M, Vermi AC, et al. (2012) Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models . J Am...
To address the roles for signals through a T cell costimulatory molecule, OX40 on the homeostatic proliferation of effector memory CD4T cells, we have set up several experimental settings, in which polyclonal effector memory (CD44CD62L) CD4T cells were transferred into lymphopenic recipient mice....
Thy1.1+CD8+ cells retrieved 80 days after transfer (approximately 60 days after rejection of the allogeneic RIP-LTα graft) had also divided and acquired a CD44hi phenotype, consistent with naïve to memory T-cell differentiation (Figure 5). These cells were predominantly CD62Lhi, suggesting ...
Cells were sorted into CD4+CD62L+CD44−CD25− naive T cells (TNs) and CD4+CD62L−CD44+CD25− effector memory cells (TEMs) using a FACS Aria (BD Biosciences). Bone marrow was depleted of T cells using Miltenyi anti-Thy1.2 microbeads and the AutoMACs cell separator (Miltenyi Biotec...
T cells (CD44hiCD62Llo, here on referred to as memory CD4 T cells) or by activating these cells in the presence of live DCs. Consistent with the existing paradigm, we found that engagement of the TCR and the co-stimulatory molecule, CD28, was sufficient for memory CD4 T cells to ...
Abstract. Circulating conventional memory CD8+ T cells (i.e., the CD8+ effector memory T [TEM] cell and CD8+ central memory T [TCM] cell subsets) and the n
(HR 0.41,p=0.015) at 30 weeks. Flow cytometric analysis performed 5 weeks post treatment demonstrated reduced proliferation of conventional CD4+T cells (0.87-fold,p=0.030) and CD8+(0.78-fold,p=0.0018) effector memory T cells in spleens of anti-CD226-treated mice. Phenotyping of pancreatic ...
We demonstrated that ADV limits the infiltration of effector memory/effector CD8 + T cells (TEM/TE) within the tumor microenvironment. To address this, we leveraged the strong capacity of NE or PPE to recruit TEM/TE by constructing novel recombinant oncolytic adenoviruses, ADVNE or ADVPPE,...