Importantly, both CD44loCD45RBhi-naive and CD44hiCD45RBhi effector/memory subsets express similar low levels of P2X7R, demonstrating that the sensitivity of CD8+ T cells to ATP depends on the stage of differentiation instead of P2X7R expression levels.-Mellouk, A., Bob茅, P. CD8+, but ...
Mesenteric lymph nodes (MLNs) and their pathogenic CD4+T cells were important to enteropathy occurrence and exacerbation when the mice were fed an egg-white (EW) diet. EW-fed OVA23-3 mice also developed bone loss and increased CD44hiCD62LloCD4+T cells in the MLNs and bone marrow (BM)...
However, there is little known about how FTY720 controls the migration property of memory T cells. Here, we demonstrated that FTY720 prevents the development of colitis induced by the adoptive transfer of lamina propria (LP) colitogenic effector memory CD4+ T cells (TEM cells; CD45RB(low)CD44...
We formally tested this concept by either strictly providing TCR and co-stimulatory signals (using plate-bound antibodies) to circulating effector memory CD4 T cells (CD44hiCD62Llo, here on referred to as memory CD4 T cells) or by activating these cells in the presence of live DCs. ...
In vivo CD44+CD8+ T cells rejected donor-type skin allografts more rapidly than naive CD8+ T cells demonstrating the ability of these putative memory T cells to mount an effective recall response in vivo. These data form the first direct demonstration that CD8+ T cells are able to generate ...
Cells were sorted into CD4+CD62L+CD44−CD25− naive T cells (TNs) and CD4+CD62L−CD44+CD25− effector memory cells (TEMs) using a FACS Aria (BD Biosciences). Bone marrow was depleted of T cells using Miltenyi anti-Thy1.2 microbeads and the AutoMACs cell separator (Miltenyi Biotec...
We phenotypically and functionally characterized the T cells of 188 well-annotated T-PLL and interrogated the modulatory impact of TCL1A. The memory-type tumor cells of no obvious clonotypic bias differed from normal T cells by high activation levels and aberrant TCR-elicited intracellular and ...
Memory CD4+Tcells primed in high-fat diet-fed donors preferentially migrated to non-lymphoid, inflammatory sites, independent of the metabolic status of the hosts. This was due to biased CD4+Tcell differentiation into CD44hi-CCR7lo-CD62Llo-CXCR3+-LFA1+effector memory-like Tcells upon priming...
memory cells21. Moreover, the cytokine receptor IL-2Rα can be an early determinant of T lymphocyte fate specification. As early as the second cell division, differences in the abundance of IL-2Rα expression in CD4+T lymphocytes responding to infection influences the TH1 cell–versus–TFH...
To address the roles for signals through a T cell costimulatory molecule, OX40 on the homeostatic proliferation of effector memory CD4T cells, we have set up several experimental settings, in which polyclonal effector memory (CD44CD62L) CD4T cells were transferred into lymphopenic recipient mice....