Effector (CD44hi, CD62L-) and central (CD44hi, CD62L+) memory T cell subsets in mouse CD3e+ and either CD4+ or CD8a+ splenocytes.Ethan, PoteetPhoebe, LewisFeng, LiSheng, ZhangJianhua, GuChangyi, ChenSam, On HoThai, DoSuMing, Chi...
by the adoptive transfer of lamina propria (LP) colitogenic effector memory CD4+ T cells (TEM cells; CD45RB(low)CD44(high)CD62L-) into severe combined immunodeficiency (SCID) mice and suppresses interferon-gamma, interleukin-2, and tumor necrosis factor-alpha production by LP CD4+ T cells....
Mesenteric lymph nodes (MLNs) and their pathogenic CD4+T cells were important to enteropathy occurrence and exacerbation when the mice were fed an egg-white (EW) diet. EW-fed OVA23-3 mice also developed bone loss and increased CD44hiCD62LloCD4+T cells in the MLNs and bone marrow (BM)...
It is well appreciated that in addition to the heterogeneity of memory T cells, heterogeneity of cell fate among the progeny of activated T lymphocytes also exists in the effector T cell population. For CD4+T lymphocytes, diversity among fate 'choices' includes various effector subsets, such as ...
Cells were sorted into CD4+CD62L+CD44−CD25− naive T cells (TNs) and CD4+CD62L−CD44+CD25− effector memory cells (TEMs) using a FACS Aria (BD Biosciences). Bone marrow was depleted of T cells using Miltenyi anti-Thy1.2 microbeads and the AutoMACs cell separator (Miltenyi Biotec...
Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an ... Vaccines capable of eliciting long-term T cell immunity are required for combating many diseases. Live vectors can be unsafe whereas...
Memory CD4+Tcells primed in high-fat diet-fed donors preferentially migrated to non-lymphoid, inflammatory sites, independent of the metabolic status of the hosts. This was due to biased CD4+Tcell differentiation into CD44hi-CCR7lo-CD62Llo-CXCR3+-LFA1+effector memory-like Tcells upon priming...
(A-B) Surface (s) marker expression (flow cytometry) in PB-derived primary T-PLL cells. (A) Distribution of sTCRα/β, sCD3, sCD28 across 143 T-PLL with no case lacking all 3 receptors. (B) Spectrum of naïve/memory differentiation on the basis of expression of CD45RA, CD45RO...
After initial stimulation, naive CD4 T cells make IL-2, which causes the cells to differentiate and may also support their survival and division. Early IL-2 can also programme responding T cells to have an increased capacity for memory survival and function7–9. However, the effect of later...
To address the roles for signals through a T cell costimulatory molecule, OX40 on the homeostatic proliferation of effector memory CD4T cells, we have set up several experimental settings, in which polyclonal effector memory (CD44CD62L) CD4T cells were transferred into lymphopenic recipient mice....