Molecular dynamics simulation of NAMB1-Ta and NAMB1-Td individually and with the cis-element motif, performed for 100ns, revealed significant variations in the protein-DNA interaction in Ta. This work provides the modelled 3D-interaction profile caused by a single bp frameshift mutation in ...
We have previously cloned a mutant hepatitis B virus (HBV) genome which had one thymidine addition in the pre-C region resulting in a frameshift mutation in the pre-C region and fusion of the X and C genes. We constructed plasmids containing serially deleted and/or back-mutated (authentic)...
Clinical and functional investigation of 10 missense mutations and a novel frameshift insertion mutation of the gene for copper-zinc superoxide dismutase i... Mutations of the gene SOD-I, which encodes the enzyme copper-zinc superoxide dismutase, occur in patients with a familial form of amyotrophic...
et al. Sinorhizobium fredii HH103 has a truncated nolO gene due to a -1 frameshift mutation that is conserved among other geographically distant S. fredii strains. Mol. Plant-Microbe Interact. 15, 150–159 (2002). 52. Vincent, J. M. The modified Fahraeus slide technique. In A manual ...
Owing to the high genotypic and phenotypic disease heterogeneity, effects and consequences of the majority of the CFTR mutations have not yet been studied. Recently, the frameshift mutation 3905insT was identified as the second most frequent mutation in the Swiss population and found to be ...
Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives. Hypertens Res. 2004 ;27:333-8 6. Nakano Y, Ishida T, Ozono R, Matsuura H, Yamamoto Y, Kambe M, Chayama K, Oshima T. A frameshift mutation of beta subunit of epithelial sodium ...
We have previously described a spectrum of mutations scattered throughout the ATP2C1 gene in HHD patients (2, 19). Although nonsense, frameshift, and splice-site mutations are predicted to cause nonsense-mediated mRNA decay (20) or aberrant splicing, the underlying cause of disease in patients ...
Frameshift mutagenicity was confined to the fl... JP Brown,PS Dietrich - 《Mutation Research/genetic Toxicology》 被引量: 456发表: 1979年 The effect of flavonoids on aerobic glycolysis and growth of tumor cell Certain bioflavonoids inhibit the glycolysis of variety of tumor cells by interfering ...
The result of this deletion is a frameshift (FSC) resulting in a PTC at codon 60. We have analyzed the impact of this mutation on transcription and translation of the affected -globin gene using an in vitro model. The quantitative real-time polymerase chain reaction (qReTi-PCR) analysis ...
The first patient carries two heterozygous frameshift mutations, 蔚127ins5 and 蔚1293insG. The second patient is homozygous for the 蔚C142Y mutation that curtails AChR expression to 22% of wild-type in HEK cells. Treatment with pyridostigmine and 3,4-diaminopyridine had a limited beneficial ...