Which share a structural feature, the EFhand (Fig. 2.1, top). The annexin protein family, whose members interact with phospholipids and cellular membranes in a calcium-dependent manner. These proteins show a high degree of sequence homology and share a repetitive conserved sequence. This segment ...
structuretermedEF-handwhichisresponsiblefortheCa 2+ binding(Babuetal.1985;Babuetal.1988;Kuboniwaetal. 1995;Zhangetal.1995),hasbeenfoundinmorethan50%of CaBPs(Zhouetal.2006).Untilnow,theproteinfamily havingEF-handshasbeenreportedtoinclude66subfamilies ...
R. Celio, "The EF-hand Ca2+-binding protein super-family: a genome-wide analysis of gene expression patterns in the adult mouse brain," Neuroscience, vol. 294, pp. 116-155, 2015.Girard F, Venail J, Schwaller B, Celio MR (2015) The EF-hand Ca2+-binding protein super- family: A ...
The EF-hand motifs in protein molecules are usually tandemly repeated, and the number of repeats ranges from two to eight. The presence of five-EF-hand proteins was not recognized until X-ray crystallographic analyses of the Ca2+-binding domains of the rat and pig calpain small subunits in ...
The majority of Ca2+-binding proteins belong to the EF-hand proteins, which contain a motif characterized by a helix–loop–helix structure, with an interhelical loop of 11 to 14 amino acids that can bind to Ca2+ ion13. In plants, the major family of EF-hand Ca2+-binding proteins ...
Grancalcin is a recently described Ca2+-binding protein especially abundant in human neutrophils. Grancalcin belongs to the penta-EF-hand subfamily of EF-hand proteins, which also comprises calpain, sorcin, peflin, and ALG-2. Penta-EF-hand members are typified by two novel types of EF-...
Ca 2+ -independent binding of an EF-hand domain to a novel motif in the α-actinin-titin complex. Nat Struct Biol. 2001; 8 :853–857. [ PubMed ]Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, et al. Ca2 + −independent binding of an EF-hand ...
(CH) domains, all three plastins contain two N-terminal EF-hand Ca2+-binding motifs which together are homologous to a single lobe of the well-known calcium-regulatory protein calmodulin. This part of the protein allows for the regulation of the actin bundling activity in response to elevated...
A multigenic family of Ca2+-binding proteins of the EF-hand type known as S100 comprises 19 members that are differentially expressed in a large number of cell types. Members of this protein family have been implicated in the Ca2+-dependent (and, in some cases, Zn2+- or Cu2+-dependent)...
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