A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors 喜欢 0 阅读量: 113 作者:D Lapin,V Kovacova,X Sun,JA Dongus,JE Parker 摘要: Plant intracellular nucleotide-binding/leucine-rich repeat (NLR) immune receptors are activated by pathogen effectors ...
An EDS1-SAG101 complex interacts with NRG1, and EDS1-PAD4 with ADR1, in an immune-activated state. NRG1 requires an intact nucleotide-binding P-loop motif, and EDS1 a functional EP domain and its partner SAG101, for induced association and immunity. Thus, two distinct modules (NRG1/...
EDS1, PAD4, and SAG101 are common regulators of plant immunity against many pathogens. EDS1 interacts with both PAD4 and SAG101 but direct interaction between PAD4 and SAG101 has not been detected, leading to the suggestion that the EDS1-PAD4 and EDS1-SA
SAG101isrequiredforR-mediated resistancetoTCV,thusimplicatingarolefortheternarycomplexinthisdefenseresponse.However,onlyEDS1isrequired forHRT-mediatedHRtoTCV,whileonlyPAD4isrequiredforSA-dependentinductionofHRT.Together,theseresults suggestthatEDS1,PAD4andSAG101alsoperformindependentfunctionsinHRT-mediatedresistance...
We report the crystal structure of an Arabidopsis EDS1-SAG101 heterodimer and a derived EDS1-PAD4 heterodimer structural model. Our analysis provides a molecular basis for actions of exclusive EDS1 heterodimers with each partner in immunity. Results Distinct EDS1 Family Member Clades Are Maintained...
AtEDS1-AtSAG101-AtNRG1 cell death activity is transferable to the Solanaceous species Nicotiana benthamiana and cannot be substituted by AtEDS1-AtPAD4 with AtNRG1 or AtEDS1-AtSAG101 with endogenous NbNRG1. Analysis of EDS1-family evolutionary rate variation and heterodimer structure-guided ...
EDS1 and SAG101, but not PAD4. An EDS1-SAG101 complex interacts with NRG1, and EDS1-PAD4 with ADR1, in an immune-activated state. NRG1 requires an intact nucleotide-binding P-loop motif, and EDS1 a functional EP domain and its partner SAG101, for induced association and immunity. ...
Driven by an N-terminal 伪/尾-hydrolase-folded domain with a protruding interaction helix, EDS1 assembles with two homologs, phytoalexin-deficient 4 (PAD4) and senescence-associated gene 101 (SAG101). The resulting heterodimers are critical for EDS1 function and structurally well characterized. ...
In Arabidopsis, three lipase-like regulators, SAG101, EDS1, and PAD4, act downstream of resistance protein-associated defense signaling. Although the roles of SAG101, EDS1, and PAD4 in biotic stress have been extensively studied, little is known about their functions in plant responses to ...
Disruption of the Arabidopsis Defense Regulator Genes SAG101, EDS1, and PAD4 Confers Enhanced Freezing Tolerance拟南芥 抗冻性 防卫基因 非生物胁迫 中断 冻结温度 突变体 L系统vip分子植物(英文版)Qin-Fang Chen[1,3] Le Xu[1,3] Wei-Juan Tan[1,3] Liang Chen[1] Hua Qi[1] Li-Juan Xie[1] ...