Although the roles of SAG101, EDS1, and PAD4 in biotic stress have been extensively studied, little is known about their functions in plant responses to abiotic stresses. Here, we show that SAG101, EDS1, and PAD4 are involved in the regulation of freezing tolerance in Arabidopsis. With ...
种子植物的EDS1蛋白家族成员包括EDS1、SAG101和PAD4,EDS1调控植物激素和NLR蛋白介导的免疫信号,对植物抵抗活体营养型病原菌尤其重要。EDS1与SAG101或PAD4形成异源二聚体,介导免疫信号传导。拟南芥和烟草中EDS1基因的进化分析与功能研究发现,EDS1-SAG101异源二聚体和含有CC结构域HET-S以及LOP-B结构域的helper NLR...
NLR不仅可以作为病原体相关分子模式的受体,同时也是信号传导的关键,因此对NLR功能及其遗传特性的理解可以为作物遗传改良提供基础。 NLR可以参与植物免疫的下游关键信号传导,其中EDS1(ENHANCED DISEASE SUSCEPTIBILITY 1)、PAD4(PHYTOALEXIN DEFICIENT 4 )和SAG101(SENESCENCE ASSOCIATED GENE 101 )组成的信号网络涉及到大多...
Its PAD4/SAG101 anchoring helix is disordered unless engaged in protein/protein interactions. As in the complex with SAG101, monomeric AtEDS1 has a substrate-inaccessible esterase triad with a blocked oxyanion hole and without space for a covalent acyl intermediate. These new structures suggest ...
A coevolved EDS1–SAG101–NRG1 module mediates cell death signaling by TIR-domain immune receptors. Plant Cell 31, 2430–2455 (2019). Article CAS PubMed PubMed Central Google Scholar Cui, H. et al. A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in...
EDS1 - PAD4 - ADR1s 和 EDS1 - SAG101 - NRG1s 在 ETI 诱导的生长停滞中的差异作用 以往对脂肪酶样 / 辅助 NLR 突变体的免疫表型研究,都是在 PTI 存在的情况下激活 ETI 时进行的,因此这些结果在多大程度上是 ETI 特异性的并不明确。在本研究中,研究人员利用 β - 雌二醇(E2)诱导表达 AvrRps4 的...
Mutational analysis of the EDS1-SAG101 heterodimer and a derived EDS1-PAD4 structural model shows that EDS1 signals within mutually exclusive heterocomplexes. Although there is evolutionary conservation of α/β hydrolase topology in all three proteins, a noncatalytic resistance mechanism is indicated....
EDS1(enhanced disease susceptibility 1)是一种重要的防卫基因,其编码的信号蛋白质位于植物免疫信号网络的关键节点。EDS1的互作蛋白质包括PAD4(phytoalexin defi ciency 4)和SAG101(senescence-associated gene 101)。EDS1在以TIR-NB-LRR(toll-interleukin-1 receptornucleotide binding-leucine-rich repeat)类R蛋白(...
The enhanced disease susceptibility 1 (EDS1) family of three lipase-like proteins, EDS1, senescence-associated gene 101 (SAG101) and phytoalexin deficient 4 (PAD4), constitutes a major NLR immunity signalling node27.EDS1is essential for TNL-dependent ETI across flowering plant species26,28,29...
EDS1 forms several molecularly and spatially distinct complexes with PAD4 and a newly discovered in vivo signaling partner, SENESCENCE ASSOCIATED GENE 101 (SAG101). Together, EDS1, PAD4 and SAG101 provide a major barrier to infection by both host-adapted and non-host pathogens. 展开 ...