(b), the compound 2 generates a compound 3 under the action of strong base in an absolute ethanol solution; (c), the compound 3 generates a compound 4 in an ammonia and ethanol solution; (d), the compound 4 reacts with a protecting group of amino under the action of a catalyst, ...
CRYSTAL FORM OF EDOXABAN TOSYLATE MONOHYDRATE AND METHOD OF PRODUCING SAMEDisclosed is a novel crystal form for a compound having an activated clotting factor X inhibiting action and is useful as a medicinal compound for prevention and/or treatment of clotting and/or embolic disorders. Specifically ...
Objectives The anticoagulant drug edoxaban has a blood thinning mechanism of action. In this study, a pencil graphite electrode was electrochemically activated at 1.4 V for 60 s. in a Britton-Robinson (pH 9.0) supporting electrolyte solution. Evidence acquisition A simple, ...
(V).In addition, the compound of formula (VI) is reactedAlternatively, the compound shown in formula (IV) is directly reacted under the action of alcohol and acid to obtain the compound shown in equationThe compound shown in equation (VI) is alkaline hydrolysisThe compound shown in formula...
As long as essential similarities exist in the mechanism of action of unfractionated heparin and direct oral anti-Xa inhibitors, we hypothesized that PiCT would accurately determine the drug concentrations of rivaroxaban, apixaban, and edoxaban. We further hypothesized that PiCT would adequately predict ...