certain P-glycoprotein inhibitors.15There is no approved reversal agent for edoxaban; however, coagulation factor Xa (recombinant), inactivated-zhzo (Andexxa) is potentially effective based on its mechanism of action. SeeChapter 4: Anticoagulation Management in the Periprocedural Periodfor more details...
MECHANISM OF ACTION : Factor X Inhibitor. In tests on rats, administration of N 1>-(4-chlorophenyl)-N 2>-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide (Ia) (10 mg/kg orally) reduced...
Mechanism of Action 12.2 Pharmacodynamics 12.3 Pharmacokinetics 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility 14 CLINICAL STUDIES 14.1 Nonvalvular Atrial Fibrillation 14.2 Treatment of Deep Vein Thrombosis and Pulmonary Embolism 16 HOW SUPPLIED/STORAGE AND HANDLING 17 ...
Objectives The anticoagulant drug edoxaban has a blood thinning mechanism of action. In this study, a pencil graphite electrode was electrochemically activated at 1.4 V for 60 s. in a Britton-Robinson (pH 9.0) supporting electrolyte solution. Evidence acquisition A simple, ...