2018). Current medications for OA are symptom-based and can provide temporary relief from the disease, mainly focusing on alleviating pain and joint stiffness, while maintaining physical joint function. Nonetheless, they have many side effects (Latourte et al. 2020). Thus, there is an urgent ...
22,23. To examine whether increased membrane CoQ10level influences BC cell mechanical properties, we directly measured single-cell cortical stiffness using Atomic Force Microscopy (AFM)24. We found that CoQ10-supplemented BC cells exhibited higher cortical stiffness, compared...
ECM-cell junctions elevate intracellular ROS levels via integrins, subsequently activating tyrosine kinase Src. Redox regulation of Src mediates integration independent EGFR trans-phosphorylation [66]. Activated Src elicits EGFR downstream signaling (AKT and ERK) in a ligand-independent manner, ultimately ...
Several post processing parameters are computed both during the mechanical and diagnostic tests: 1) maximum/minimum cyclic displacement and strain; 2) tangent stiffness (calculated as the slope between the maximum and minimum force and displacements for each cycle); 3) stress (calculated as the ...
We propose an update of the theoretical framework of immunosenescence, based on a novel hypothesis: the increasing stiffness and cross-linking of the senescent ECM lead to a progressive immunodeficiency due to an age-related decrease in T cell mobility and eventually the death of these cells. A ...
Additionally, we observed reduced expression of the antioxidant enzymes SOD2 (27%) and Catalase (82%) in BCEC plated at 2 kPa, further supporting the notion that stiffness alterations may influence ROS production in these cells. We observed decreased Integrins 伪5/尾3 (28%/38%) expression ...
MMP-2 knockdown blunts age-dependent carotid stiffness by decreasing elastin degradation and augmenting eNOS activation. Cardiovasc Res. 2022;118(10):2385–96. https://doi.org/10.1093/cvr/ cvab300. Feng M, Ding J, Wang M, Zhang J, Zhu XH, Guan WX. Kupffer-...
Matrix stiffness-induced gemcitabine resistance correlated with the upregulation of ABC transporters and oxidative stress adaptive responses. While gemcitabine activated Nrf2 expression, promoting oxidative stress mitigation, Gem-S suppressed Nrf2 levels and induced oxidative stress, leading to increased ...
Image-based finite element mechanical models predicted an increase in the transverse relative to longitudinal (muscle fiber direction) stiffness, with the stiffness ratio (transverse/longitudinal) increased in the mdx model compared to the WT at three and six months. This study highlights that the ...
The repair is characterized by an inflammatory process that leads to an impaired build-up of the ECM of the dermis, resulting in a dysfunctional tissue and presenting: (i) a high rate of differentiation of fibroblasts into myofibroblast lineage (ii) increased collagen content and stiffness, (iii...