ECL CELLSGASTRINOMEPRAZOLERATSHISTAMINEDuring recent years, the so-called ECL cells of the acid-producing part of the stomach have attracted much attention, mainly due to the fact that mice and rats were found to develop gastric carcinoids (ECL cell tumors) following lifelong treatment with ...
The acid-producing part of the stomach is rich in peptide-hormone-producing endocrine/paracrine cells of different types. In birds and all mammals studied, ECL cells constitute the quantitatively predominant endocrine cell population in this location. They produce histamine and an as yet unidentified ...
During recent years, the so-called ECL cells of the acid-producing part of the stomach have attracted much attention, mainly due to the fact that mice and rats were found to develop gastric carcinoids (ECL cell tumors) following lifelong treatment with blockers of acid secretion. These observa...
Enterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL cells or increased production from progenitors has not been clarified. Methods We used mice with ...
ECL cells in the oxyntic mucosa of the mouse and rat stomach express CCK2 receptors, which enable them to respond to gastrin by the production and release of histamine. We have studied CCK2 receptor-deficient mice and rats subjected to pharmacological CCK2 receptor blockade in an attempt to ...
Using immunohistochemistry at the conventional light, confocal and electron microscopic levels, we have demonstrated that rat stomach ECL cells store histamine and pancreastatin in granules and secretory vesicles, while histidine decarboxylase occurs in the cytosol. Furthermore the ECL cells display immunore...
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Exocytotic proteins in enterochromaffin-like (ECL) cells of the rat stomach Histamine (HA), contained in the enterochromaffin-like (ECL) cells of the gastric mucosa in animals, plays an important role in gastric acid secretion, alt... Chun-Mei,Zhao,Gunilla,... - 《Cell & Tissue Research》...
ECL cells in the oxyntic mucosa of stomach control gastric acid secretion by mobilizing histamine in response to gastrin. They respond to gastrin also with hypertrophy and hyperplasia. ECL cells exhibit functional impairment upon long-term gastrin stimulation. The impairment is manifested in a gradual...
Gastrin (g) and enterochromaffin: Like (ecl) cells in the stomach of portocaval-shunted rats: Radioimmunological, immunocytochemical and ultrastructural studyportacaval shuntratgastrinenterochromaffin-like cellsThe aim of the study was to monitor the changes observed in the concentration of gastrin, as...