Previously, we identified 2 ecdysteroid kinase-like (EcKL) genes-Wallflower (Wall) and Pinkman (pkm)-in the model fruit fly Drosophila melanogaster that are orthologs of the ecdysteroid 22-kinase gene BmEc22K. Here, using gene knockdown, knockout, and misexpression, we explore Wall and pkm's ...
Ecdysteroids are polyhydroxylated sterols, and are widespread in the plant and animal world. To date, over 520 ecdysteroids have been isolated from natural sources. The most accessible and studied representative of this class of compounds is 20-hydroxyecdysone (20E)—a universal hormone for the de...
Audit-Lamour, C., and Busson, D. (1981). Oogenesis defects in theecd-1mutant ofDrosophila melanogaster, deficient in ecdysteroid at high temperature. J. Insect Physiol.27, 829–837. ArticleCASGoogle Scholar Badisco, L., Claeys, I., Van Loy, T., Van Hiel, M., Franssens, V., Simone...
Inacute myeloid leukemia(AML), ecdysteroids have been studied as an alternative to steroids like dexamethasone, which are frequently used in combination with chemotherapy and radiation during treatment. 20HE showed positive results inin vitrostudies, decreasing the proliferation of cancer cells, increasin...
Stimulation of the PG by neuropeptides involves several signaling cascades, including a cAMP-dependent pathway, a classical mitogen-activated protein kinase cascade, and an S6 kinase pathway (3, 5, 6). These pathways control synthesis of ecdysteroids from dietary cholesterol or phytosterols via a ...
The lKCs show preferential expression of five genes encoding proteins involved in Ca2+-signaling, such as Ca2+/calmodulin-dependent protein kinase II (CaMKII)19, which plays a central role in the synaptic plasticity that serves as a platform for learning and memory processes in many animal ...
B. The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis. Science 326, 1403–1405 (2009). 22. Nu¨sslein-Volhard, C. & Wieschaus, E. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster I. Zygotic loci on the second ...
Ecdysteroid kinase-like (EcKL) paralogs confer developmental tolerance to caffeine in Drosophila melanogasterdoi:10.1101/2021.09.15.460555Jack L. ScanlanPaul BattlayCharles RobinCold Spring Harbor Laboratory
Identifying candidate detoxification genes in the ecdysteroid kinase-like (EcKL) and cytochrome P450 gene families in Drosophila melanogaster by integrating evolutionary and transcriptomic datadoi:10.1101/2020.02.17.951962Scanlan JlGledhill-Smith RsBattlay P...
Bioinformatics analysis of BmIGFLP promoter sequence revealed three cis-regulation elements (CREs) of signal transducer and activator of transcription (STAT), which is a key component in the Janus-activated kinase / STAT pathway. Luciferase activity assays showed that two CREs enhanced the ...