EBVHIVGranzyme BDLBCLAims: A new subtype of granzyme B (GrB) producing "regulatory B cells" (Bregs) has been recently described; these peculiar cytotoxic B-cells are significantly increased in interleukin-21 (IL-21)-rich settings, and in particular during HIV and EBV infection. Our aim is ...
Currently, there is no efficacious drug for EBV-positive DLBCL. The cytokine interleukin-21 (IL-21) has been reported to be pro-apoptotic in DLBCL cell lines and is being explored as a new therapeutic strategy for this type of lymphomas. However, our previous studies showed that IL-21 ...
Immunohistochemical expression of MUM1. MUM1 is a plasma cell marker and, in DLBCL, is consistent with a non-germinal center subtype. DLBCL with a non-germinal center profile have been associated with worse survival (100×) Immunohistochemical detection of EBV-encoded RNA (EBER). Nuclear expressi...
Epstein-Barr virus–positive (EBV+) diffuse large B-cell lymphoma of the elderly (DLBCL-E), first described by Oyama et al,1,2 is a provisional entity in the 2008 World Health Organization (WHO) classification of lymphoid neoplasms,3 accounting for 3% to 14% of DLBCL cases.2,4, 5, 6...
Table 4. NF-kB pathway activation in EBV-positive DLBCL of the (a) elderly vs EBV-negative DLBCL; (b) elderly vs EBV-DLBCL (only ABC type cases) Empty CellNoYesTotal (a) Np52 Series EBV-positive DLBCL of the elderly 11 32 43 EBV-negative DLBCL 180 79 259 Total 191 111 302 Pea...
(W) Abbreviations: EBV, Epstein–Barr virus; IC-DLBCL, diffuse large B-cell lymphoma in immunocompetent patients; LR, log-rank test (most sensitive for differences in late survival times); PT-DLBCL, post-transplant diffuse large B-cell lymphoma; W, Wilcoxon test (most sensitive for ...
positivediffuselargeB-celllymphoma(DLBCL),anaggressivenon-Hodgkinlymphomawithpoorclinical outcomes.WeusedEBV-positiveandEBV-negativeDLBCLcelllinesandgeneratedtwoEBV-transfected celllines,LY7/EBVandU2932/EBV.RomidepsinwascytotoxictoculturedEBV-positivecellsviatheac- tivationofthecaspasecascade.Moreover,invivomice...
Keywords: Epstein-Barr virus (EBV); deoxyuridine triphosphate nucleotidohydrolase (dUTPase); Toll-like receptor 2 (TLR2); diffuse large B cell lymphoma (DLBCL); chronic lymphocytic leukemia (CLL) 1. Introduction Epstein-Barr virus, which is a γ herpesvirus, is a ubiquitous virus that ...
T-cell lymphomaLYMPHOMASDIAGNOSISDIFFERENTIAL diagnosisThere may be significant histopathologic overlap between EBV﹑ositive DLBCL, NOS, and other diagnoses including angioimmunoblastic Tヽell lymphoma (AITL). Resolution of this differential diagnosis may be particularly challenging and require extensive ...
The programmed death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in the pathogenesis of Epstein-Barr virus-positive diffuse large B cell lymphoma, not otherwise specified (EBV+ DLBCL, NOS). Here, we describe PD-L1 expression by EBV+ DLBCL, NOS in order to evaluate its possi...