EBV+ DLBCL有两种不同的组织学模式:(a)单形性,表现为大细胞为主,呈弥漫性分布,需要与浆母细胞淋巴瘤(PBL)、HHV8+DLBCL NOS、原发性渗出性淋巴瘤(PEL)和伯基特淋巴瘤(BL)相鉴别;(b)多形性,大细胞分散在反应性背景中,有大量小淋巴细胞或组织细胞。需要与慢性炎症...
定义EBV阳性弥漫性大B细胞淋巴瘤(EBV+DLBCL)是一种大B细胞淋巴瘤,大多数肿瘤细胞被EB病毒感染。患者没有淋巴瘤或潜在的免疫缺陷/失调病史(免疫衰老除外)。该肿瘤不应满足其他EB病毒相关的淋巴组织增生性疾病或淋巴瘤的诊断标准。临床特点患病人群:大多数发生于50岁以上患者,少数年轻患者也可发病。发病部位:年轻患者主...
10. Ohashi A, Kato S, Okamoto A, Inaguma Y, Satou A, Tsuzuki T, et al. Reappraisal of Epstein-Barr virus (EBV) in diffuse large B-cell lymphoma (DLBCL): comparative analysis between EBV-positive and EBV-negative DLBC...
Minimal dot-like expression of GrB was found in 7 lymphomas (in less than 1% of tumour cells), 3 of which were EBV-positive. Conclusions: Breg origin has never been reported in B-cell lymphomas. We describe an exceptional case of EBV-positive DLBCL with aberrant expression of cytotoxic ...
myc-FISH:myc-,BCL-2-诊断:老年EBV阳性弥漫大B细胞淋巴瘤(EBV-positiveDLBCLoftheelderly)21第21页EBV-VCAIgG+EBV-VCAIgM–EBNA-1IgG+EBV-EAIgG+提示EBV激活EBV-DNA- 22第22页2023 WHO分类DiffuselargeB-celllymphoma(DLBCL),NOS T-cell/histiocyte-richlargeB-celllymphoma PrimaryDLBCLoftheCNS Primarycutaneous...
EBV-positive diffuse large B-cell lymphoma in young adults: is this a distinct disease entity? [J]. Ann Oncol, 2015, 26(3): 548-555. [9] 刘琳, 高子芬, 李敏, 等. EB病毒阳性的胃弥漫大B细胞淋巴瘤特点及预后[J].中国肿瘤临床, 2016, 43(6): 255- 259. LIU L, GAO Z F, LI M, ...
The cytokine interleukin-21 (IL-21) has been reported to be pro-apoptotic in DLBCL cell lines and is being explored as a new therapeutic strategy for this type of lymphomas. However, our previous studies showed that IL-21 stimulation of EBV-positive DLBCL cell lines leads to increased ...
seropositive. EBV expression has also been reported in patients with diffuse large B-cell lymphoma (DLBCL) [6]. DLBCL is the most common variant of non-Hodgkin lymphoma in the United States (US) and accounts for approximately 25–30% of the cases [7]. In Peru, DLBCL accounts for up ...
EB病毒(EBV)阳性弥漫性大B细胞淋巴瘤(EBV-positivediffuselargeB-celllymphoma,EBV+DLBCL)因其具有独特的临床病理特征及发病机制,在2008年修订版造血和淋巴组织肿瘤世界卫生组织(WHO)分类中,将EBV+DLBCL分为一种独立的疾病类型。将50岁以上的DLBCL伴EB病毒(EBV)感染的单克隆B细胞增殖性疾病同时满足免疫功能健全和既往...
2.弥漫大B细胞淋巴瘤,腿型(DLBCL):皮肤肿瘤结节,镜下肿瘤细胞成片浸润破坏性生长,免疫母细胞样,很少或没有被景炎性细胞,EBV阴性,临床过程为侵袭性,广泛扩散。 3.浆母细胞淋巴瘤(PBL):也多发生于口腔,但绝大多数患者有HIV感染病史。肿瘤细胞成片,曾浆母细胞样或免疫母细胞样形态,CD138+,CD79a+,MUM-1+,CD2...