病程中查血(血浆)EBV-DNA 10*4-10*5Copies/ml,影像学检查示双侧颈部及双侧咽后区多发淋巴结肿大,鼻咽软组织增厚,双侧腭扁桃体肿大;先后于多家医院行肿物活检及会诊,考虑为EBV阳性的T淋巴组织细胞增殖性疾病(I-II级,1年7月前)。入院查体:右侧颈部可...
今日消息,威斯津生物在全球首次启动了治疗EBV病毒相关恶性肿瘤的mRNA疫苗药物的注册临床试验。 根据clinicaltrials.gov网站显示,一项名为“Application of mRNA Immunotherapy Technology in Epstein-Barr Virus-related Refractory Malignant Tumors...
However, the interrogation of a gp350 vaccine in a phase II clinical trial showed that it was unable to prevent EBV infection. Our laboratory has recently developed a vaccine candidate in the form of defective EBV particles. These defective particles lack viral DNA, are non-infectious and are ...
To facilitate the rational design and assessment of an effective vaccine, we systematically reviewed pre-clinical and clinical prophylactic EBV vaccine studies to determine the antigens, delivery platforms, and animal models used in these studies. Methods:We searched Cochrane Library, ClinicalTrials.gov...
mRNA疫苗由威斯津生物的联合创始人宋相容教授牵头研发,历时长达5年。部分研究成果于2013年1月已发表于国际期刊Nano Research,题名为:A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma。动物试验研究显示,mRNA疫苗可显著抑制针EBV阳性肿瘤细胞的生长,安全性较好。
Is there light at the end of the tunnel leading to a safe and effective Epstein-Barr Virus (EBV) vaccine for use in specific groups at risk of EBV diseases? In this issue of the Journal, Rees et al. (1) report the results of a phase 1 st... Allen,D Upton - 《Transplantation》 ...
with bladder cancer, kidney cancer and cutaneous squamous cell carcinoma Advanced three new vaccine programs (Epstein-Barr virus, Varicella-Zoster virus, norovirus) toward Phase 3 clinical trials as announced at Vaccines Day investor event CAMBRIDGE, MA / ACCESSWIRE / May 2, 2024 / Moderna, Inc....
Another vaccine that researchers are studying produced a strong immune response against EBV in mice. Whether it will work in humans still has to be proved. Right now, the best way to avoid the virus is to stay away from anyone who you know is infected, and especially someone who has mono...
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Our near-term focus, however, remains progressing ELI-002, our cancer vaccine candidate for mutant KRAS-driven solid tumors, through the ongoing phase 1 trials and to a randomized trial in pancreatic cancer in 2024." Elicio首席执行官罗伯特·康纳利补充说:“我们对AMP平台的多功能性以及淋巴结靶向在...