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RecordID=198440, identifier PROSPERO I.D. CRD4202019844. 展开 关键词: Epstein-Barr virus cancer glycoprotein herpesvirus infectious mononucleosis neutralizing antibody pre-clinical prophylactic vaccine DOI: 10.3389/fimmu.2022.867918 年份: 2022
Epstein-Barr病毒(EBV)属于疱疹病毒科γ亚科,具有噬B淋巴细胞的特性,能够在B淋巴细胞中建立起潜伏感染,刺激细胞的增生和转化.人群中有大于90%的感染率.虽然大部分EBV感染的个体一直处于无症状状态,EBV的感染却增加了发展成不同恶性肿瘤的危险,1997年世界卫生组织国际癌症研究机构(LARC)的报告中已将EBV归类为对人致癌...
除此之外 EBV 还与鼻咽癌(nasopharyngeal cancer, NPC)、Hodgkin’s 淋巴瘤、Burkitt 淋巴瘤、胃癌、以及获得性免疫缺陷综合症(Acquired Immune Deficiency Syndrome, AIDS)患者的口腔毛状白斑症等发生发展密切相关。因此,开发 EBV 疫苗用于预防或治疗这些疾病具有极大的临床意义。 关键词:EBV,预防性疫苗,治疗性疫苗 15...