药物: 达沙替尼 伊马替尼 PDGFB 基因突变与药物 EBF1-PDGFRB PDGFB 基因突变 EBF1-PDGFRB Allele Registry ID:别名: ClinVar ID: 基因突变位点 Ref. Build: Ensembl Version: null Chr. Start Stop Ref. s Var. Bases null null Transcript 基因序列移动...
AGGF1-PDGFRB, AGGF1-PDGFRB C843G PDGFRB 基因突变 EBF1-PDGFRB Allele Registry ID:别名: ClinVar ID: EBF1-PDGFRB融合与缺乏BCR-ABL融合的ph样急性淋巴细胞白血病有关。病例报告显示伊马替尼治疗有阳性反应。EBF1-PDGFRB fusions are associated with Ph-like acute lymphoblastic leukemia lacking the BCR-ABL ...
急性淋巴细胞白血病(ALL)是儿童的主要恶性肿瘤之一。随着芯片和新测序技术的应用,在ALL中发现了很多具有预后意义的重现性遗传学异常,如超二倍体、亚二倍体、郑佳佳苏州大学附属第一医院陈苏宁苏州大学附属第一医院孙爱宁苏州大学附属第一医院吴德沛苏州大学附属第一医院vip中华血液学杂志...
Effective treatment with imatinib for acute B-lymphoblastic leukaemia with EBF1-PDGFRB fusionACUTE leukemiaIMATINIBLYMPHOBLASTIC leukemiaCORD blood transplantationAnnals of Hematology -doi:10.1007/s00277-020-04332-8Springer Berlin HeidelbergAnnals of Hematology...
Conversely, PDGFRB is a receptor tyrosine kinase that is normally repressed in lymphocytes, yet PDGFRB remains a common fusion partner in leukemias. Here, we demonstrate that the EBF1-PDGFRB fusion results in loss of EBF1 function, multimerization and autophosphorylation of the fusion protein, ...
先后予化疗、伊马替尼以及嵌合抗原受体T细胞(CAR-T)输注等综合治疗.结果 患者初诊时骨髓标本经全外显子测序检测到EBF1-PDGFRB融合基因,经过综合治疗后PDGFRB重排持续阴性,至截稿前患者获得持续分子生物学缓解已22个月.结论 联合化疗、CAR-T细胞输注及酪氨酸激酶抑制剂等综合治疗能促进EBF1-PDGFRB阳性Ph样ALL患者获得...
EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications. Blood. 2016; 127:2214-2218.Schwab C, Ryan SL, Chilton L, et al. EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): ...
Since further investigation revealed EBF1-PDGFRB fusion, her condition was treated as BCR-ABL1-like acute lymphoblastic leukemia. She was started on a tyrosine kinase inhibitor, imatinib, and chemotherapy and underwent umbilical cord blood transplantation following reduced intensity conditioning. She has ...
PDGFRB EBF1-PDGFRBEBF1-PDGFRB融合与缺乏BCR-ABL融合的ph样急性淋巴细胞白血病有关。病例报告显示伊马替尼治疗有阳性反应。EBF1-PDGFRB fusions are associated with Ph-like acute lymphoblastic leukemia lacking the BCR-ABL fusion. Case reports have shown positive responses to imatinib treatment....
PDGFB EBF1-PDGFRB 别名 Allele Registry ID: ClinVar ID:突变位点 Ref. Build: Ensembl Version: null Chr. Start Stop Ref. s Var. Bases null null Transcript基因序列 癌基因 靶向药 医生 医院癌症分类 肺癌 乳腺癌 胃癌 肝癌 结直肠癌 食管癌 子宫癌 卵巢癌 宫颈癌 前列腺癌 脑瘤 胰腺癌 膀胱癌...