We previously manually curated a set of 289 experimentally verified IBD genes, which are published as IBDDB database (https://www.cbrc.kaust.edu.sa/ibd/) (Khan et al.2021). The IBD genes were analysed to identify (transcription start site (TSS)) in their promoters in EPDnew (https://...
Methods: The study was a randomized, placebo-controlled, double blind trial comparing three doses (low, medium, and high) of a new uro-selective alpha-blocker with an active comparator. A total of 536 men aged 40 years and older with lower urinary tract symptoms (LUTS) resulting from BPH...
i had sex a week ago...the condom came off inside me...and i've been nauseus everyday since then...is this coincidence...are these symptoms of morning sickness? cud i be pregnant? me n my boyfriend dnt kno when the condom came off...we're really worried. please help! Remove...
Studies in humans and animal models indicate that ELS increases risk for depression by sensitizing individuals to stress later in life, leading to a first appearance or synergistic worsening of depression-like symptoms5,6,7,8,9. Stress early in life can alter developmental brain trajectories, and...
of reducing the symptoms and progression of early OA are non-pharmacological therapies, such as weight control and appropriate exercise1,5. To properly initiate these treatments, a reliable early diagnosis of articular cartilage damage is essential. The existence of a tool that allows repeated ...
Under the general assumption that the symptoms of neural disorders are the result of broad enough neuronal malfunction, two extreme scenarios may explain this process. The first is the deterministic model. In this model, the WT and mutant cells both function normally at early development. However,...
Briefly, the patients were early treatment-naïve RA patients whose symptoms had lasted less than six months. Upon entry into this double-blind study, patients were randomized to conventional methotrexate (MTX) treatment plus placebo (disease-modifying anti-rheumatic drug (DMARD)) or MTX in ...
TSS is the treatment of choice for acromegaly. Cure is defined by normalization of age-related IGF-1 and sufficient suppression of GH in the oral glucose tolerance test (OGTT). We investigated, if early postoperative hormone testing gives reliable information whether complete resection of a tumor ...
However, to our knowledge, this is the first report that a single oligonucleotide (GapmeR) targeting a lncRNA which hosts a cluster of miRNAs can control the expression of the host lncRNA, component miRNAs, their targets, profibrotic genes and symptoms of DN in mice, and in human MC. ...
We found no differences in DNA methylation between men who were separated from their families and non-separated men; however, we did identify differences in DNA methylation in association with the development of at least mild depressive symptoms over the subsequent 5–10 years. Notably, ...