The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cells required for healthy brain function becomes pe...
Herba CM, Tremblay RE, Boivin M, Liu X, Mongeau C, Séguin JR, Côté SM (2013) Maternal depressive symptoms and children’s emotional problems: can early child care help children of depressed mothers? JAMA Psychiat 70(8):830–838. https://doi.org/10.1001/jamapsychiatry.2013.1361 Article...
The mouse mutant Motor neuron degeneration (Mnd) displays an adult-onset progressive degeneration of upper and lower motor neurons, with mild symptoms recognizable at 6 months, leading to spastic paralysis and premature death at 10-12 months on the C57B1/6 background. Despite this late onset, ...
We conducted various motor behavioral tests at different ages to determine the time of disease onset and the stages of disease progression. We tested motor coordination and balance using the Rotarod assay that measures the length of time before a mouse falls from an accelerating rod (at 6, 10,...
symptoms and signs of HD [6]. The hypothalamus has been shown to be affected more than a decade prior to the onset of clinical disease [1,2], with pathological changes in the hypothalamus associated with the early non-motor features of HD [25,26]. Other parts of the limbic system have...
Mice overexpress- ing ALS-linked mutant SOD1 develop ALS symptoms accompanied by histopathological alterations and protein aggregation. The protein disulfide isomerase family member ERp57 is one of the main up-regulated proteins in tissue of ALS patients and mutant SOD1 mice, whereas point mutations ...
Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice overexpressing ALS-linked mutant SOD1 develop ALS symptoms accompanied by histopathologi...
Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci U S A. 2010;107(47):20523–8. Article PubMed CAS Google Scholar Amaratunga A, Fine RE. Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in ...
The first RCT of MT with ALS found that active MT increased communication, improved QoL and decreased the physical symptoms of the disease for participants during hospital stay [63]. Music-assisted relaxation may be a useful strategy to optimize the non-invasive ventilation experience for pwALS [...
[4]. Pharmacologic therapies can improve heart function in the short term and relieve the symptoms associated with CHF, but are unable to restore and maintain normal heart function over the long term [5,6]. Therefore, decades of development work have focused on cardiac assist devices (CADs) ...