amyloidosiscarrierdiagnosishereditaryfollow upminimum criteria for diagnosispredicted age of disease onsettransthyretinDiagnosis in the early stages of hereditary transthyretin (ATTR) amyloidosis is imperative to support timely treatment to prevent or delay disease progression. Genetic testing in the setting of...
Early-onset Alzheimer’s disease (EOAD) is a rare but particularly devastating form of AD. Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same neuropathological hallmarks underlying the more common, late-onset form of AD. In this review, we describe the...
amyloidosiscarrierdiagnosishereditaryfollow upminimum criteria for diagnosispredicted age of disease onsettransthyretinDiagnosis in the early stages of hereditary transthyretin (ATTR) amyloidosis is imperative to support timely treatment to prevent or delay disease progression. Genetic testing in the setting of...
Multiple PET-to-autopsy studies have shown that amyloid-PET is a reliable marker of fibrillar β-amyloid pathology [84,85,86], although the earliest stages of amyloidosis (Thal stages 1–2 [87]) might not be detected [88, 89]. Unlike most neuroimaging modalities, the regional distribution ...
LDLR has the highest affinity for ApoE and plays an important role in brain cholesterol metabolism [35]. LDLR is one of the molecules that is involved in the clearance of amyloid proteins in the AD brain [36]. LDLR-deficient mice developed age-dependent cerebral β-amyloidosis. Cao et al....
which 184 biomarkers were measured in pEVs, cerebrospinal fluid (CSF), and plasma samples using multiplex PEA technology of Olink©proteomics. The obtained results showed that proteins measured in pEVs from EOMCI patients with established amyloidosis correlated with CSF p-tau181levels, brain ...
In general, MR relaxometry has been applied for various cardiac applications such as the detection of changes in the microvascular structure in hypo-perfused areas by T2* measurements40,41, or the quantification of the degree of amyloidosis in the myocardium in T1 and T2 parameter maps42. ...
Dry eyes can be caused by amyloidosis, inflammation (chronic blepharitis or conjunctivitis, pemphigoid, or Stevens-Johnson syndrome), SS, neurologic conditions that impair eyelid or lacrimal gland function, sarcoidosis, toxicity (burns or drugs), and a variety of other conditions (corneal anesthesia,...
vascular amyloidosis in postmortem retinas from AD patients, there was an early and progressive loss of retinal vascular PDGFRβ in pericytes and vSMCs that associated with AD pathology in the brain. Materials and methods Human eye and brain donors...
Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia 2010; 58: 300–314. 56. Bialowas-McGoey LA, Lesicka A, Whitaker-Azmitia PM. Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing ...