Evaluation of the cytokine profile at the earliest time points after onset of symptoms could identify novel targets that prevent progression to chronic arthritis.doi:10.1156/ar1780GS FiresteinBioMed CentralArthritis Research & TherapyFirestein GS (2005) Pathogenesis of rheumatoid arthritis: how early is ...
Early-Onset Osteoporosis as a Sequelae of Other Illness Idiopathic Osteoporosis Genetic Determinants of Osteoporosis Monogenic Bone Fragility Due to Impaired WNT-Signaling Activity X-Chromosomal Osteoporosis Due to PLS3 Mutations Osteoporosis Caused by SGMS2 Variants Early-Onset Osteoporosis as a Polygenic ...
Results: Eighty patients were enrolled, mean age 49.7 ± 14.0 years, mean disease duration 5.3 ± 3.5 months (at symptoms onset). Among these, 15% were in drug-free remission, 61% in monotherapy with csDMARDs 61%, and 24% in combination therapy with csDMARDs+bDMARDs. Overall rates of...
In treatment-naïve early rheumatoid arthritis patients, plasma CXCL13 levels were associated with joint inflammation. Furthermore, patients with high baseline plasma CXCL13 levels had an improved chance of remission after 2 years. We propose that high CXCL13 concentrations indicate recent onset of ...
Rheumatoid arthritis: Pathogenesis and early recognition Rheumatoid arthritis (RA) is a chronic, destructive disease characterized by joint pain and swelling, which progresses in a substantial percentage of patie... P Barland 被引量: 48发表: 1996年 Very recent onset rheumatoid arthritis: clinical an...
MR imaging is a useful technique in diagnosis, follow-up, and evaluation of remission in rheumatic diseases of the joints. Early diagnosis of RA, in the first 6 months after the onset of symptoms, may lead to earlier control and prevent future erosions and deformities....
Patients could soon be diagnosed with early-stage arthritis several years before the onset of physical and irreversible symptoms, thanks to a new test developed by researchers at the University of Warwick. Led by Dr Naila Rabbani of Warwick Medical School, the researchers developed a test that can...
which is typically considered a polygenic disorder with onset in early adulthood2. A20 is a potent inhibitor of the NF-κB signaling pathway3. Mutant, truncated A20 proteins are likely to act through haploinsufficiency because they do not exert a dominant-negative effect in overexpression experiments...
Background: 0.5% to 0.8% of all adults suffer from rheumatoid arthritis (RA). The main considerations for persons with new-onset RA are early diagnosis, disease-modifying anti-rheumatic drugs (DMARDs), remission, and interdisciplinary treatment. Method: As part of the process of creating a new...
Thirty-four patients diagnosed as RA by 2010 ACR/EULAR criteria; with the onset of symptoms within last one year, were included in the study after institute ethical clearance and informed consent to undergo USG and contrast-enhanced MRI of the dominant affected hand. Second to fifth metacarpopha...