Kung TN, Bykerk VP. Detecting the earliest signs of rheumatoid arthritis: symptoms and examination. Rheum Dis Clin North Am 2014;40:669-83.Kung TN, Bykerk VP. Detecting the earliest signs of rheu- matoid arthritis: symptoms and examination. Rheum Dis Clin North Am 2014; 40(4): 669-683.
Therefore, we investigated CD4+ T-helper cell subsets in lymph node biopsies and peripheral blood during the earliest phases of RA. Methods Nineteen individuals with arthralgia but without arthritis, who were positive for IgM rheumatoid factor (IgM-RF) and/or anti-citrullinated protein antibodies (...
Background Systemic autoimmunity may precede the development of clinical signs and symptoms of seropositive rheumatoid arthritis (RA), which offers a window of opportunity to delay or prevent clinically manifest arthritis by targeted intervention. This could represent a paradigm shift from treatment to ...