Together, these data argue in favour of a stronger and persistent activation of astrocytes in db/db mice in the post-acute phase of stroke probably in link with a higher brain damage size and delayed activation
astrocytes in the cerebellum, the Müller glia cells in the retina or the pituicytes in the neurohypophysis [17,29,30,31,32]. In addition to these general features common to all mammalian brains, hominid primates exhibit evolutionary unique subtypes of astrocytes, i.e. the interlaminar and v...
Early life experiences can influence the development and function of astrocytes, potentially impacting the neural circuits they interact with [157,158]. As the resident immune cells of the brain, microglia play a crucial role in immune surveillance and response to injury or infection. Early ...
We recently highlighted a novel potential protective paracrine role of cardiac myeloid CD11b/c cells improving resistance of adult hypertrophied cardiomyocytes to oxidative stress and potentially delaying evolution towards heart failure (HF) in response
rMCMV-infected mouse embryonic fibroblasts showed lytic infection and activation of both promoters, while virus-infected cerebral neurons in primary neuronal cultures demonstrated the non-lytic and persistent infection as well as the activation of e1-pro-1373, but not -448. In the rMCMV-infected ...
Second, the trials allow for flexible dose adjustment, including dose reductions and extension of dose-escalation intervals. Finally, treatment pauses of no fixed length are allowed to improve tolerability in the event of persistent GI-related adverse events. The rationale for studying semaglutide in ...
we have shown that ES leads to persistent alterations in microglia up to the age of 10 months. Microglia are essential in the immune response to Aβ [39] and exhibit an aggravated inflammatory response to Aβ pathology in AD mice previously exposed to ES [14]. However, astrocytes are al...
In con- trast, VIP has been linked to most of the neuropeptide immu- nomodulatory actions and has been explored as a potential anti-inflammatory target in animal models of Parkinson's disease, where a single intracerebroventricular injection of VIP was able to reduce microglial activation and ...
This profile correlated with a wound healing signature in astrocytes and impaired myelination in oligodendrocytes, while pericyte profiles indicated vascular abnormalities. Conversely, single-nuclei signatures in mice lacking DAP12 signaling reflected very mild microglial defects that did not recapitulate NHD....
of astrocytes, oligodendroctyes, and microglial cells, which play a role in remodeling of synapses [31,32], and the related process ofmyelination, the increase of myelin that facilitates the structural neural connections that buttress functional connectivity, occurs throughout development at varying ...