This profile correlated with a wound healing signature in astrocytes and impaired myelination in oligodendrocytes, while pericyte profiles indicated vascular abnormalities. Conversely, single-nuclei signatures in mice lacking DAP12 signaling reflected very mild microglial defects that did not recapitulate NHD....
We recently highlighted a novel potential protective paracrine role of cardiac myeloid CD11b/c cells improving resistance of adult hypertrophied cardiomyocytes to oxidative stress and potentially delaying evolution towards heart failure (HF) in response
hypothalamic circuitry involved in appetite control; this may affect the expression patterns of neuropeptides released by leptin-regulated anorexigenic or orexigenic neurons and cause sustained activation of glial cells (such as astrocytes and microglia), which may lead to hypothalamic inflammation [28]....
rMCMV-infected mouse embryonic fibroblasts showed lytic infection and activation of both promoters, while virus-infected cerebral neurons in primary neuronal cultures demonstrated the non-lytic and persistent infection as well as the activation of e1-pro-1373, but not -448. In the rMCMV-infected ...
Summary: In the hippocampus there is a graded vulnerability of neuronal subpopulations to hypoglycemia-induced degeneration, most likely due to excitotoxic activation of glutamate receptors. The present study was conducted to investigate whether the induction of transcription factors of the immediate early...
Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase Free Radic. Biol. Med. (2012) V.Brancoet al. Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds ...
Many of the persistent impairments and disabilities experienced by TBI survivors are caused by the potentially preventable secondary injury. Despite a greater understanding of the pathophysiology of TBI in recent years, current treatment is largely supportive, with no clinically proven treatments ...
Early-life adversity (ELA) and stress promote vulnerabilities to stress-related affective disorders, yet it is unknown how transient ELA dictates lifelong neuroendocrine and behavioral reactions to stress. The population of hypothalamic corticotropin-releasing factor (CRF)–expressing neurons that regulate ...
In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and membrane-bound proteins. An imbalanced astrocyte activity can therefore have drastic negative impacts on brain devel
of astrocytes, oligodendroctyes, and microglial cells, which play a role in remodeling of synapses [31,32], and the related process ofmyelination, the increase of myelin that facilitates the structural neural connections that buttress functional connectivity, occurs throughout development at varying ...