48]. There are more than 600 different RING type ligases expressed in human cells [49]. During ubiquitination process, the RING domain of RING E3 ligases binds the E2 conjugation enzyme. Contrary to HECT E3 ligases, the Ub is transferred from the E2 ...
E3 ligases interact with both the target protein and the E2 enzyme.Search Main menu Skip to primary content Skip to secondary content Home TF mRNA Auranofin Chloroquine GANT61 MF-438 MolidustatThe particular prevalence along with factors related to alcohol use dysfunction between individuals coping ...
PROTACs have been explored in multiple disease fields with focus on only few ligases like cereblon (CRBN), Von Hippel-Lindau (VHL), IAP and MDM2. Cancer targets like androgen receptor, estrogen receptor, BTK, BCL2, CDK8 and c-MET [[6], [7], [8], [9], [10], [11]] have been ...
defects. Moreover,estrogen receptor β(ERβ) agonist was found to promote PTEN nuclear transport in PCa, andRNA sequencingrevealed that NEDD4 and PTEN were both downregulated in the Erβ−/− mouse ventral prostate[60]. Altogether, the NEDD4-PTEN pathway mediated by PMEPA1 is involved in...
on ERα re-expressed by 5-aza-dC in TNBC cells, and its expression was also upregulated through EREs within the promoter region of RNF208 upon E2 treatment, indicating that RNF208 is a novel estrogen-inducible target gene in an ERα-dependent manner. Moreover, overexpression of RNF208 ...
E2's Ubiquitin conjugating enzymes E3's Ubiquitin ligase enzymes EGFR Epidermal growth factor receptor Endo G Endonuclease G ER Endoplasmic reticulum ERα Estrogen receptor alpha ERKs Extracellular-signal-regulated kinase EZH2 Enhancer of zeste homolog 2 eIF4E Eukaryotic translation initiation factor 4E eIF...
超过75%的乳腺癌为HR阳性,其中绝大部分患者需要接受内分泌治疗,包括:抗雌激素(estrogen receptor,ER)治疗,即选择性雌激素调节剂(selective ER modulators,SERMs)、选择性雌激素下调剂(selective ER degraders,SERDs);芳香化酶抑制剂(aromatase inhibitors,AIs);卵...
图11 亮丙瑞林3月 & 1月剂型vs戈舍瑞林治疗1年期间E2、FSH水平对比 此外,GnRHa 3月剂型与1月剂型均可改善绝经前早期乳腺癌患者的长期预后,亮丙瑞林3月剂型联合他莫昔芬治疗5年DFS可达 90.4%;另一项研究中,戈舍瑞林1月剂型联合...
Plasma estrogen and androgen levels are positively associated with postmenopausal breast cancer risk, but how long a single blood measurement can predict risk and whether the associations vary by tumor hormone receptor status remain unclear. We conducted nested case–control analyses within the Nurses' ...
AC, doxorubicin/cyclophosphamide; ER, estrogen receptor; PR, progesterone receptor. Results HER-2状态对DFS的影响( 5年随访结果) 有170例患者接受了HER-2状态的检测,其中有46例为HER-2 阳性(27%),127例为HER-2阴性(73%)。经过5年随访, HER-2阳性患者DFS较HER-2阴性者差。 无论HER-...