Correlation of dyskerin expression with active proliferation independent of telomerase. Head Neck. 2010 In press.Faizan Alawi, Ping Lin, Barry Ziober, Reena Patel. (2011) Correlation of dyskerin expression with active proliferation independent of telomerase. Head & Neck 33 :10.1002/hed.v33.7, 1041-...
Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Tissue Specificity: Ubiquitously expressed. Involvement in Disease: Dyskeratosis congenita, X-linked: A rare, progressive bone marrow failure syndrome ...
DKC1 performs two fundamental functions for cell proliferation. First, DKC1 is a component of the H/ACA small nucleolar ribonucleoprotein particles (snoRNPs) involved the pseudouridylation of ribosomal RNA (rRNA) molecules and necessary for their processing. Second, it is required for telomerase act...
TelomeraseClear cell renal cell carcinoma (ccRCC) displays sex-biased incidence, outcomes, molecular alterations and treatment efficacy; however, clinical managements are largely identical in male and female patients. Moreover, many biomarkers have been identified as predictors for ccRCC outcomes and ...
Signs and symptoms of DKC; Function of telomerase; How a mutation of dyskerin could cause a deficiency in telomerase.ShayJerryW.WrightWoodringE.EBSCO_AspScienceShay,J.W. and Wright,W.E. (1999) Mutant dyskerin ends relationship with telomerase. Science, 286, 2284±2285....
Decreased dyskerin levels were associated with compromised telomerase RNA levels and very short telomeres. These data identify decreased dyskerin levels as a novel mechanism of DC, and indicate that intact dyskerin levels, in the absence of coding mutations, are critical for telomerase RNA stability ...
980 Telomerase is a ribonuclear protein complex that functions to maintain the integrity of chromosomal-end structures (telomeres), and thereby enables continued cell replication. The active telomerase holoenzyme includes telomerase reverse transcriptase (hTERT) as its catalytic core, an RNA component (...
Synthesis, chromen, anticancer activity, dyskerin, telomerase activityA series of new trimethoxyphenyl-4H-chromen derivatives as telomerase inhibitors through regulation dyskerin were designed and synthesised. The anticancer activity assay in vitro showed that compound 5i 3-(4-(4-isonicotinoylpiperazin-1-...
CBs also contribute to the delivery of telomerase to telomeres. The protein WRAP53 is enriched within the CB and is instrumental for the targeting of telomerase RNA to CBs. Two other CB proteins, SMN and coilin, are also suspected of taking part in some aspect of telomerase biogenesis. Here...
After testing the accumulation of a series of mouseH/ACA snoRNA in Del15 ES cells, we found a decrease of the mU68and mE1 snoRNAs suggesting the mutation may also confer effectswhich are outside the telomerase pathway. We therefore wenton to produce a line of mice expressing the truncated...