Telomerase, which is active early in development and later in stem and germline cells, is also active in the majority of human cancers. One of the known functions of telomerase is to extend the ends of linear chromosomes, countering their gradual shortening at each cell division due to the en...
cell lines (Fig. 2b,candSupplementary Fig. 2a,b). Of note, the numbers of 53BP1 foci tend to correlate with the amount of excessive DNA (Supplementary Fig. 2c). Treatment with the replication inhibitor aphidicolin further increased the number of 53BP1 foci in the tested cell lines (...
Augmented telomerase activity, reduced telomere length and the presence of alternative lengthening of telomere in renal cell carcinoma: plausible predictive and diagnostic markers. Gene 2015;562:145-51.Pal D, Sharma U, Khajuria R, Singh SK, Kakkar N, Prasad R. Augmented telomerase activity, ...