Here, we demonstrated that rhesus monkeys under short-term broad-spectrum antibiotic treatment could be used as a model to study the gut mucosal host-microbiome niche and immune balance with steady health status. Results showed that the diversity and community structure of the gut commensal bacteria...
Dysbiosis of gut microbiota could regulate N AD+ anabolic pathway to affect the occurrence and development of PD. As a NAD+ anabolic pathway-related gene, NMNAT2 was poorly expressed in the brain tissues of PD patients. More importantly, FMT or overexpression of NMNAT2 alleviated neuro...
research has focused on the dysbiosis of gut microbiome in UC. However, the results so far remain inconsistent and insufficient to understand the microbial component in UC pathogenesis. In this study, we determine specific
The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients. Through 16S rRNA gene sequencing, 728 samples are collected to identify mic
We know that each person has a unique combination of species in their gut, and that each person’s gut microbiome is different. However, many of those species perform similar functions and now scientists have the technology to look at the functions of those bacteria – i.e. not who they ...
Clinical microbiota analysis and animal studies in germ-free or antibiotic-treated mice have been crucial for improving our understanding of the role of the microbiome on the host mucosal surface; however, studies on the mechanisms involved in microbiome-host interactions remain limited to small ...
Dysbiosis of gut microbiome is commonly occurred in intensive care unit (ICU) patients during the process of disease due to critical illness, stress and intensive care which induced a significant morbidity and mortality. A number of strategies including rational use of antibiotics, early enteral nutri...
inthegutmicrobiotaisinvolvedwiththedevelopmentofcolorectalcancer.Inthiscase,dysbiosismaynotbethemostimportantfactor,rathertheproductsofinteractionbetweendietandthemicrobiome.High-proteindietsarethoughttoresultintheproductionofcarcinogenicmetabolitesfromthecolonicmicrobiotathatmayresultintheinductionofneoplasiainthecolonic...
Gut microbiota dysbiosis is a condition that occurs when there is an imbalance in the composition of the gut microbiome. The gut microbiome is a complex ecosystem of microorganisms that reside in the gastrointestinal tract and play a crucial role in maintaining the overall health of the human body...
Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogensIn Parkinson's disease (PD), gastrointestinal features are common and often precede the motor signs. Braak and colleagues proposed that PD may start in the gut, triggered by a pathogen, and spread...