Dynamin-related protein-1 (Drp1) is a key regulator in mitochondrial fission. Excessive Drp1-mediated mitochondrial fission in skeletal muscle under the obese condition is associated with impaired insulin action. However, it remains unknown whether pharmacological inhibition of Drp1, using the Drp1-...
Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal fission. Recent studies propose that Drp1 does not sever but rather constricts mitochondrial membranes allowing dynamin 2 (Dnm2) to execute final scission. Here, we report that unlike Drp1, Dnm2 is dispensable for ...
Recent studies have demonstrated that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, mediates mitochondria-dependent apoptosis through mitochondrial division. However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity...
8a,b). To confirm that the increase in Drp1 oligomers was not due to a change in the total Drp1 protein levels, we conducted Western blot analyses on whole cell lysates and observed no difference in total Drp1 protein levels after treatment (Fig. 5c; Supplementary Fig. 8c). This indicates...
Dynamin-related protein 1 as a therapeutic targetin cardiac arrest. Sharp WW. Journal of Molecular Medicine . 2015Sharp, Willard W..Dynamin-related protein 1 as a therapeutic target in cardiac arrest[J].2015,93(3).Sharp WW. Dynamin‑related protein 1 as a therapeutic target in cardiac ...
Dynamin-Related Protein 1 Inhibitors Protect against Ischemic Toxicity through Attenuating Mitochondrial Ca2+ Uptake from Endoplasmic Reticulum Store in PC12 Cells. Tian Y,Li B,Shi W. International Jouranl of Molecular Sciences . 2014Tian Y Li B Shi WZ . Dynamin-related protein 1 inhibitors protect...
Dynamin-related protein 1 ECAR: Extracellular acidification rate Fis1: Fission 1 FITC: Fluorescein isothiocyanate ICAM-1: Intercellular adhesion molecule-1 JAMs: Junctional adhesion molecules LDH: Lactate dehydrogenase activity LPS: Lipopolysaccharide OCR: Oxygen consumption rate PD: Parkinson ...
related protein-1 (Drp1), thereby decreasing Drp1 accumulation in mitochondria and Drp1-mediated activation of the mitochondrial fission program. We also found that p53 transcriptionally downregulates miR-499 expression. Our data reveal a role for miR-499 in regulating the mitochondrial fission machinery...
Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂,抑制了DRP1(发动蛋白相关GTP酶)和Dynamin I (Dnm1)的IC50为1-10 μM。 靶点(IC50 & Targe) Dnm1 GTPase,1μM-10μM 体外研究 Mdivi-1是一个可以穿越细胞膜的喹唑酮类化合物,抑制了酵母的Dnm1和人源的Drp1分裂DRPs(发动蛋白相关GTP酶),并且高...
However, we report that GSSG, but not reduced GSH, prevents ischemic supersulfide catabolism-associated heart failure in male mice by electrophilic modification of dynamin-related protein (Drp1). In healthy exercised hearts, the redox-sensitive Cys644 of Drp1 is highly S-glutathionylated. Nearly ...