ProteinsAprotininX-Ray DiffractionProtein ConformationBiophysicsBiophysical PhenomenaFourier AnalysisMotionThermodynamicsModels, MolecularThe dynamics of a folded globular protein (bovine pancreatic trypsin inhibitor) have been studied by solving the equations of motion for the atoms with an empirical potential ...
Vibrational dynamics of folded proteins is studied using a Gaussian model in which the protein is viewed as a network, residues representing the junctions, and the connectivity being established by a single parameter harmonic potential. Application to seven proteins showed that the local packing density...
The dynamics of a folded protein is studied in water and glycerol at a series of temperatures below and above their respective dynamical transition. The system is modeled in two distinct states whereby the protein is decoupled from the bulk solvent at low temperatures, and communicates with it th...
A model for the production of incorrectly folded intermediates is suggested and some numerical estimates made. Implications and future directions in the evolution of the model are discussed. Three appendices deal with some mathematical aspects of the model.doi:10.1002/bip.360210703...
McCammon JA, Gelin BR, Karplus M: Dynamics of folded proteins. Nature. 1977, 267: 585-590. 10.1038/267585a0. Article CAS PubMed Google Scholar Cornell WD, Cieplak P, Bayly CI, Gould IR, Merz KM, Ferguson DM, Spellmeyer DC, Fox T, Caldwell JW, Kollman PA: A second generation forc...
McCammon, J., Gelin, B., Karplus, M.: Dynamics of folded proteins. Nature 267 (1977) Google Scholar Micheletti, C., Marenduzzo, D., Orlandini, E.: Polymers with spatial or topological constraints: theoretical and computational results. Phys. Rep. 504(1), 1 (2011) Article ADS MathSc...
Deniz2,z The temperature-jump technique, in which the sample is rapidly heated by a powerful laser pulse, has been widely used to probe the fast dynamics of folding of proteins and nucleic acids. However, the existing temperature-jump setups tend to involve sophisticated and expensive ...
Vibrational dynamics of folded proteins: significance of slow and fast motions in relation to function and stability Phys. Rev. Lett., 80 (1998), p. 2733 View in ScopusGoogle Scholar Balci-Peynircioglu et al., 2008 B. Balci-Peynircioglu, A.L. Waite, P. Schaner, Z.E. Taskiran, N....
A Helenius - 《Journal of Cell Biology》 被引量: 361发表: 1992年 Quality control in the secretory pathway: the role of calreticulin, calnexin and BiP in the retention of glycoproteins with C-terminal truncations. Unlike properly folded and assembled proteins, most misfolded and incompletely assem...
McCammon JA, Gelin BR, Karplus M (1977) Dynamics of folded proteins. Nature 267(5612):585–590. doi:10.1038/267585a0 CAS Google Scholar Xu M, Lill MA (2011) Significant enhancement of docking sensitivity using implicit ligand sampling. J Chem Inf Model 51(3):693–706. doi:10.1021/ci...