This article presents a model for the HLA effect in insulin-dependent diabetes mellitus (IDDM) that is almost the mirror image of a model suggested by Nepom. In the Nepom model, the products of certain HLA alleles are associated with IDDM because they bind and present a specific peptide or ...
This year is the 100th anniversary of the discovery of insulin.Before 1921,children and adults with diabetes most often died within a few days or months.Insulin lengthens(加长) this timeline to decades. Back in the 16th century BC,there were records about this "terrible ...
A DR3-related DX alpha gene polymorphism strongly associates with insulin-dependent diabetes mellitus. Immunogenetics. 1986; 23 (1):47–51. [ PubMed ]Hitman, G.A.; Sachs, J.; Cassell, P.; et al.: A DR3-related DX alpha gene polymorphism strongly associated with insulin-dependent ...