InsulinSignaling pathwayAKT pathwayMetabolismDiabetes mellitus (T2DMDuring recent years, it has become clearer that temporal patterns of stimuli and molecules are important in the regulation of cellular functions. For example, many hormones show distinct temporal patterns in vivo, which are important for...
However, there was no association with insulin-dependent diabetes mellitus, rheumatoid arthritis, juvenile rheumatoid arthritis, multiple sclerosis, myasthenia gravis or coeliac disease. On the other hand, significant differences were found between Caucasoid and Oriental populations in frequencies of the V ...
Nature 395:462–469 Singh B, Prange S, Jevnikar AM (1998) Protective and destructive effects of microbial infection in insulin-dependent diabetes mellitus. Semin Immunol 10:79–86 Stauffer Y, Marguerat S, Meylan F, Ucla C, Sutkowski N, Huber B, Pelet T, Conrad B (2001) Interferon-α-...
Role of ncRNAs in diabetes-related T-lymphocyte dysfunction. Examples of ncRNA-dependent T cells deregulation in (a) T2DM retinopathy, (b) T2DM wound healing and (c) diabetic kidney disease. T2DM: type 2 diabetes mellitus, TGF-β: transforming growth factor-beta, FoXP3: forkhead box P3, MAP...
Because obesity decreases the sensitivity to insulin, the human ob gene is presumed to be one of the candidate genes for non-insulin-dependent diabetes mellitus (NIDDM) associated with obesity. Although the protein coding region in the ob gene has been screened for mutations, the promoter region...
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients’ health and lives. Mitochondria are core organelles for the maintenance of myocardial tissue homeostasis, and their impairment and dysfunction are considered major contribu...
[41]. Still, new family members are likely to be discovered. The expression of lncRNA is highly dependent on tissue expression. Although the expression of messengerRNA(mRNA) is both temporally and spatially unique in the adult brain, lncRNA is shown to have a higher specificity in such a ...
Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial disease (PAD). Various types of cells, including but not limited to endothelial cells (ECs), vascular smooth muscle cells
Studies to gain a deeper understanding of XIST function, and how its aberrant expression may regulate key cellular processes in a sex-dependent manner may lead to establishing XIST as a biomarker to track or predict disease progression and as a potential therapeutic target. ...
Alternative splicing is a well-known mechanism of pre-mRNA processing in higher eukaryotes. The serine/arginine (SR) splicing factors regulate cell type specific alternative splicing in a concentration and phosphorylation-dependent manner. How levels of active SR proteins are regulated is not well unde...