However, there was no association with insulin-dependent diabetes mellitus, rheumatoid arthritis, juvenile rheumatoid arthritis, multiple sclerosis, myasthenia gravis or coeliac disease. On the other hand, significant differences were found between Caucasoid and Oriental populations in frequencies of the V ...
The second example is lncRNA GAS5, whose decrease is closely related to insulin resistance and diabetes91, 92, 93, and it has been tested as a drug target through compound library screening. Briefly, Shi et al.94 synthesized a γ-AApeptide combinatorial library and employed a one-bead-two...
Type 2 diabetes (T2D) etiology is highly complex due to its multiple roots of origin. Polygenic risk scores (PRS) based on genome-wide association studies (GWAS) can partially explain T2D risk. Asian Indian people have up to six times higher risk of deve
Role of ncRNAs in diabetes-related T-lymphocyte dysfunction. Examples of ncRNA-dependent T cells deregulation in (a) T2DM retinopathy, (b) T2DM wound healing and (c) diabetic kidney disease. T2DM: type 2 diabetes mellitus, TGF-β: transforming growth factor-beta, FoXP3: forkhead box P3, MAP...
et al. Decreased transcription of ChREBP-alpha/beta isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia. Diabetes 62, 837–844 (2013). Article CAS PubMed PubMed Central Google Scholar...
Memantine is a non-competitive, moderate-affinity, voltage-dependent NMDA receptor antagonist. It blocks the action of pathologically elevated glutamate levels, which can lead to neuronal dysfunction. Glutamate-mediated neurotransmission, particularly the dysfunction of NMDA receptors, contributes to the expr...
P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 367–377 (2008). Article CAS PubMed PubMed Central Google Scholar Arner, P. et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478, ...
The expression of the CaM genes has been shown to be dependent on the physiological conditions of the cell. For instance, the half-life of CALM1 and CALM3 mRNAs is longer than the one of CALM2 mRNA in mouse myoblasts during both proliferation and differentiation, while the half-life of al...
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012;16:435–48. Article PubMed PubMed Central Google Scholar Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into ...
Metformin is a synthetic derivative of galegine and/or guanidine and belongs to a group of compounds called biguanides. galegine synthesize fromGallega officinalis, a plant that has been used for centuries in Europe to treat diabetes [33]. Metformin works by improving insulin sensitivity in patie...