However, there was no association with insulin-dependent diabetes mellitus, rheumatoid arthritis, juvenile rheumatoid arthritis, multiple sclerosis, myasthenia gravis or coeliac disease. On the other hand, sign
The second example is lncRNA GAS5, whose decrease is closely related to insulin resistance and diabetes91, 92, 93, and it has been tested as a drug target through compound library screening. Briefly, Shi et al.94 synthesized a γ-AApeptide combinatorial library and employed a one-bead-two...
Type 2 diabetes (T2D) etiology is highly complex due to its multiple roots of origin. Polygenic risk scores (PRS) based on genome-wide association studies (GWAS) can partially explain T2D risk. Asian Indian people have up to six times higher risk of deve
Role of ncRNAs in diabetes-related T-lymphocyte dysfunction. Examples of ncRNA-dependent T cells deregulation in (a) T2DM retinopathy, (b) T2DM wound healing and (c) diabetic kidney disease. T2DM: type 2 diabetes mellitus, TGF-β: transforming growth factor-beta, FoXP3: forkhead box P3, MAP...
et al. Decreased transcription of ChREBP-alpha/beta isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia. Diabetes 62, 837–844 (2013). Article CAS PubMed PubMed Central Google Scholar...
Memantine is a non-competitive, moderate-affinity, voltage-dependent NMDA receptor antagonist. It blocks the action of pathologically elevated glutamate levels, which can lead to neuronal dysfunction. Glutamate-mediated neurotransmission, particularly the dysfunction of NMDA receptors, contributes to the expr...
P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 367–377 (2008). Article CAS PubMed PubMed Central Google Scholar Arner, P. et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478, ...
The expression of the CaM genes has been shown to be dependent on the physiological conditions of the cell. For instance, the half-life of CALM1 and CALM3 mRNAs is longer than the one of CALM2 mRNA in mouse myoblasts during both proliferation and differentiation, while the half-life of al...
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012;16:435–48. Article PubMed PubMed Central Google Scholar Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into ...
From these typings, it can be seen that an individual typed positive for D/DR4 has a 6.4 times higher risk of developing insulin-dependent diabetes than individuals typed negative for D/DR4. In some cases it has also been demonstrated that a disease is more severe in patients having the dis...