Within wild type axons, NFs are responsible for mediating radial growth, a process that determines axonal diameter. NFs are phosphorylated on highly conserved lysine-serine-proline (KSP) repeats located along the C-termini of both NF-M and NF-H within myelinated axonal regions. Phosphorylation ...
Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. The nuclear envelope is a dynamic structure that completely disassembles in response to MPF cdc2 activity in mitosis. A key feature of this process is the ... R Heald,F Mckeon - 《Cell》 被引量...
Collectively, these data indicate that N-cadherin upregulation in CK2-mediated E-cadherin to N-cadherin switching is dependent on phosphorylation-mediated MZF1 stabilization. CK2 could be a good therapeutic target for the prevention of metastasis....
Using 3F3/2, an antibody that detects the level of phosphorylation of a kinetochore protein or proteins, we have determined that this reorientation is not accompanied by a change in the level of phosphorylation of the kinetochores of either X or Y. This implies that: i) either the ...
Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-Like Kinases (TLKs). Here, we identify TLK phosphorylation sites by mass spectrometry and dissect how phosphorylation impacts on human Asf1 function. The divergent C-terminal tail of Asf1a is ...
TheRoleofPhosphorylationinRedoxRegulationPhotosynthesisGenespsaA MolecularPlant·Volume2·Number3·Pages416-429·May2009RESEARCHARTICLETheRoleofPhosphoryIatiOninRedoxRegulationofPhotosynthesisGenespsaAandpsbAduringPhOtOsyntheticAcclimationofMustardSebastianSteiner。,LarsDietzel,YvonneSchr6ter。,VidalFey-_,RaikWagner。·...
Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) to glycolysis or alterations in other metabolic pathways. However, most of the experimental findings have been acquired in murine...
Regeneration is a complex multi-step process involving many cell types and pathways. Healing is sometimes considered as the initial step of regeneration [11]. Immediately after injury, the cell sheets around the wound are activated to prevent further loss of biological material. In fishes and amphi...
In the brain, increased neural activity is correlated with increases of cerebral blood flow and tissue oxygenation. However, how cerebral oxygen dynamics are controlled in the behaving animal remains unclear. We investigated to what extent cerebral oxyge
we identify THEMIS as an uncharacterized substrate for the phosphatase SHP1. Saturated mutagenesis assays and mass spectrometry analysis reveal that phosphorylation of THEMIS at the evolutionally conserved Tyr34 residue is oppositely regulated by SHP1 and the kinase LCK. Similar toTHEMIS−/−mice,TH...