features of antigen-presenting cells. However, their ability to contribute to the antigen-specific activation of T cells in vivo is controversial. The expression of selected cell surface, cytoplasmic and endosomal molecules, as well as some of the key nuclear transcription factors controlling their de...
Thus CNS APC, though essential for the initiation of disease, also play a downregulatory role. The mechanisms by which CNS APC limit the expansion of autoreactive T cells in the target organ include their production of NO and their decreased antigen presenting capability late in disease. Other ...
granulocytic compartment. These results suggest that tumor and treatment-mediated B-cell depletion together with chronic antigen presentation to effector cells, which are classical hallmarks of immune dysfunction in MM, can be depicted through immune profiling of blood samples. Fig. 2: Immune composition...
T cells sensitized previously by pulsed macrophage (1 degree APC) were cultured in mixture with macrophage pulsed by same antigen (2 degrees APC). An antigen special lymphocyte transformation test in vitro was used to evaluate the antigen presentation ability of spleen macrophage from mice of late...
and nucleic acids, for example, they are involved in various biological processes such as angiogenesis, antigen presentation, apoptosis, and inflammation play a role. Furthermore, research has demonstrated a strong correlation between illnesses and the molecular constituents present within exosomes [43–...
Zinc supplementation to younger subjects (19–31 years of age, 15 mg Zn per day as ZnSO4), resulted in increased mRNA production of TNF-α and IL-1β in LPS-treated monocytes and granulocytes, and augmented IFN-γ mRNA in T cells treated with microbeads to simulate antigen presentation [...
The meeting was structured by the agenda and presentations, followed by adequate time for discussions at the end of each presentation (Additional file 3). Below, the major discussions of the meetings, specifically on the practicalities of expanding roles of VMWs aligning with the current policy ...
The complex interactions resulting in the generation of T-cell–mediated alloimmune responses depend on antigen presentation, cognate interactions between donor T cells and antigen-presenting cells (APCs), and the concomitant production of soluble and membrane-bound costimulatory molecules by APCs and T...
‘non-self’ antigens, the host immune system requires the participation of receptors of immune cells. TCR of T and BCR of B lymphocytes can recognize allogeneic ‘non-self’ MHC antigens, leading to the activation of T and B lymphocyte-mediated rejection. However, the mere involvement of ...
we assessed the presentation of WT and C3 KO mice following HSV-1 infection using spectral domain-optical coherence tomography (SP-OCT) and found the corneas of the C3 KO mice to show a trend for greater edema than their WT counterparts at day 5 and 7 pi (Supplementary Fig.1S). However...