Ferroptosis, a pro-inflammatory programmed cell death driven by the accumulation of iron-dependent peroxidative polyunsaturated fatty acids in cell membranes, has attracted great attention as a potential anti-tumor strategy for years [6]. However, few clinical trials were conducted for cancer therapy ...
There are several difficulties in the evaluation of the intrinsic radiation effects on heart-related deaths. First of all, the confounding effects of chemotherapy is inevitable in breast cancer treatment. Cardiac dysfunctions caused by chemotherapeutic agents such as doxorubicin, taxol, and trastuzumab ha...
or were taking medication for DM (n = 2609); if they had a previous diagnosis of pancreatic cancer (n = 55) at baseline; or if the final histology of an incident pancreatic tumour confirmed a PanNEN (ICD-10 C254 and/or an ICD-0-3 histology code corresponding to PanNEN) (n = 73)...
(1) Background: The aim of this study was to identify risk factors for distant metastasis of pancreatic ductal adenocarcinoma (PDAC) and develop a valid predictive model to guide clinical practice; (2) Methods: We screened 14328 PDAC patients from the Su
however selective CDK4/6 inhibitors, such as PD-0332991 (palbociclib) or LY2835219 (abemaciclib), have emerged as a powerful class of agents with clinical activity in a number of malignancies, firstly demonstrated in the treatment of ER+/HER2- metastatic breast cancer [72,73], and other solid...