Compounds with furan, thiophene, pyrrole, pyridine, azole, imidazole, indole, purine, pyrimidine, esters, carboxylic acid, aldehyde, pyrylium, pyrone, pyrodine, barbituric acid, barbiturate,quinoline, quinolone, isoquinolone, coumarin, alkylpyridine, picoline, piperidine, diazine, carboxamide, flavonoid ...
Similarly, αfucosylamine linked to 2aminocyclo hexanecarboxylic acid (compound 2) mimics lewisx trisaccharide and inhibits DCSIGn with a twofold gtirveealyte)r72.pTotheensceyb(inICd5in0 g= 0.35 mM and 0.8 mM, respec affinities are too weak for these compounds to have ...
Then the QCMS were dipped into a solution of 10 mM thioctic acid (TA) in ethanol for 20 hours under nitrogen flow. The electrodes were then rinsed with absolute ethanol to remove unbound molecules of TA and were left to dry at air. Activation of carboxylic acid groups of the self-...
They can be made from many different types of polymers including: poly(L-glutamic acid) (PGA), polyamidoamine (PAMAM), poly(ethylene glycol) (PEG), and polyethylenimine (PEI). Each dendrimer consists of a multifunctional core molecule with a dendritic wedge attached to each its functional sites...
yields with high regioselectivities under mild reaction conditions by using 1,2-DTBPMB or (p-F-Ph)3P as ligand. The reaction process is operationally simple and requires no handling of toxic CO or strong acid. The resulting aryl esters can be readily converted to other carboxylic acid ...
171DRUGSUSEDFORANESTHESIAMUSCLERELAXATION用于麻醉的药物肌肉松弛This converts the ester functional group into an inactive carboxylic acid metabolite.172DRUGSUSEDFORANESTHESIAMUSCLERELAXATION用于麻醉的药物肌肉松弛This particular opioid is useful when dealing with patients with liver or kidney failure.173DRUGSUSED...
Phosphonate group is commonly used as a bioisostere of carboxylate in drug design [76]. Compared with carboxylic acid (pKa = 4.74), phosphonic acid (pKa1 = 2.38) has higher acidity and stronger electrostatic interactions with guanidinium group. In a helical protein, the formation of ...
carboxylic acid located at the 2 position on the “B” ring and have a N for the linker atom. They are also tri-substituted on the anilino-ring; however, they noticed that placing an othro-acetyl group on the anilino ring significantly increased activity of the compound, as did having ...
Two other carboxylic acid-containing drugs (clofibric acid and valproic acid) and a limited range of drugs containing an alcohol or phenolic functional group were also glucoronidated by expressed UGT2B7 variant. The deduced amino sequence of UGT2B7 variant was shown to differ only in one amino...
The material which participates in the crosslinking reaction needs a suitable functional group at the N-end, such as an amino group, phenol group, sulfhydryl group or imidazole group. With the inclusion method, the method may be classified into the lattice type in which materials to be ...